Squamous Cell Carcinoma In Situ (Bowen Disease) David Cassarino, MD, PhD Key Facts Terminology Squamous cell carcinoma in situ (SCCis) Synonyms: Bowen disease, squamous intraepithelial neoplasia Full thickness intraepidermal atypia…
Bowenoid Papulosis Elsa F. Velazquez, MD Key Facts Etiology/Pathogenesis Most often related to HPV 16 Clinical Issues Often multifocal Benign-looking papules Usually affecting skin of shaft in males Affecting labia…
Actinic Cheilitis David Cassarino, MD, PhD Key Facts Terminology Actinic cheilitis (AC) Actinic keratosis of lip Etiology/Pathogenesis Chronic sun exposure, especially UVB rays Clinical Issues Excellent in most cases, low…
Actinic Keratosis David Cassarino, MD, PhD Key Facts Terminology Actinic keratosis (AK) Solar keratosis Atypical intraepidermal proliferation of keratinocytes typically confined to basilar portion of epidermis Clinical Issues Older adults…
Toker Cell Hyperplasia Christine J. Ko, MD Key Facts Terminology Increase in number of Toker cells in epidermis Absence of underlying ductal carcinoma Mimics Paget disease of the nipple Clinical…
Clear Cell Papulosis Christine J. Ko, MD Key Facts Terminology Rare disorder Multiple, hypopigmented to white, flat-topped papules and macules Generally on lower trunk/suprapubic area Almost always in young children…
Clear Cell Acanthoma Christine J. Ko, MD Key Facts Clinical Issues Common in middle-aged women Generally on lower legs Solitary, pink-red, shiny papule or plaque Microscopic Pathology Acanthosis of pale…
Prurigo Nodularis Christine J. Ko, MD Key Facts Etiology/Pathogenesis Chronic rubbing/scratching induces discrete papules/nodules Clinical Issues Generally on extremities but sometimes on trunk or posterior scalp Microscopic Pathology Hyperkeratosis, focal…
Large Cell Acanthoma David Cassarino, MD, PhD Key Facts Terminology Proliferation of enlarged and mildly atypical keratinocytes in sun-damaged skin without diagnostic features of actinic keratosis Variously considered to be…
Condyloma Acuminatum (Genital Wart) Elsa F. Velazquez, MD Key Facts Etiology/Pathogenesis HPV-related lesion Low-risk HPV serotypes (6, 11) predominate Macroscopic Features From flat to exophilic cauliflower-like lesions Measuring from a…
