Toker Cell Hyperplasia

Toker Cell Hyperplasia

Christine J. Ko, MD

Toker cell hyperplasia is a rare histopathologic finding. Toker cells, a normal component of the nipple epithelium, are increased in number and may mimic Paget disease of the nipple.

In Toker cell hyperplasia, Toker cells are evident by light microscopy, and they are also highlighted by CK7 staining. The bland cells are scattered in the basal and suprabasal layers.



  • Increase in number of Toker cells in epidermis

  • Absence of underlying ductal carcinoma

  • Mimics Paget disease of the nipple

  • Awareness important to avoid overdiagnosis of Paget disease



Jul 8, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Toker Cell Hyperplasia

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