Large Cell Acanthoma

Large Cell Acanthoma

David Cassarino, MD, PhD

LCA shows an intraepidermal proliferation of enlarged keratinocytes in a disorganized pattern. There is no basilar budding or overlying parakeratosis typical of an actinic keratosis. Note prominent solar elastosis image in dermis.

Higher power of LCA shows enlarged keratinocytes image involving the mid to upper layers of epidermis with overlying basket-weave orthokeratosis. Dermis shows solar elastosis and mild chronic inflammatory infiltrate.



  • Large cell acanthoma (LCA)


  • Proliferation of enlarged and mildly atypical keratinocytes in sun-damaged skin without diagnostic features of actinic keratosis (AK)

    • Has been variously considered to be related to or a variant of solar lentigo, seborrheic keratosis (stucco keratosis), or AK


Environmental Exposure

  • Most cases associated with UV radiation (chronic solar damage)

Jul 8, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Large Cell Acanthoma
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