Papillary Eccrine Adenoma

Apr 24, 2017 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Papillary Eccrine Adenoma

 Evidence of apocrine glandular differentiation • Aggressive digital papillary adenocarcinoma  Larger nodular tumor with ductal structures  More cellular and shows infiltrative features • Metastatic adenocarcinoma  Cytologic atypia and mitoses usually prominent Diagnostic…

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Toker Cell Hyperplasia

Apr 24, 2017 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Toker Cell Hyperplasia

 Clinical history differs – Generally affects unilateral nipple/areola in older adults  Clear to pale cells with abundant cytoplasm scattered at all levels in epidermis  Nuclear atypia present – Hyperchromatic nuclei – Prominent eosinophilic…

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Keloid and Cellular Scar

Apr 24, 2017 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Keloid and Cellular Scar

 Superficial telangiectatic vessels often present  May be associated with mild chronic inflammation • Increased fibroblasts, lymphocytes, and mast cells usually present Top Differential Diagnoses • Hypertrophic scar  Lacks characteristic hyalinized collagen bundles…

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Median Raphe Cyst

Apr 24, 2017 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Median Raphe Cyst

 Parameatal cyst, paraurethral cyst, genitoperineal cyst, mucoid cyst • Midline developmental cyst found at any point from external urethral meatus to anus Etiology/Pathogenesis • Defective embryological closure of median raphe  Abnormal closure…

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Atypical Vascular Lesion

Apr 24, 2017 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Atypical Vascular Lesion

 Clinically presents as large, erythematous patch (median: 7 cm)  Endothelial multilayering and nuclear atypia  Mitotic figures often present  Evidence of MYC amplification by FISH or immunohistochemistry • Hobnail hemangioma • Lymphangioma circumscriptum…

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Sinusoidal Hemangioma

Apr 24, 2017 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Sinusoidal Hemangioma

 Subcutaneous or dermal mass • Excellent prognosis, no malignant potential • Complete excision is curative but not necessary given benign nature of lesions Microscopic • Well-circumscribed vascular proliferation • Vessels are thin-walled and closely…

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Large Cell Acanthoma

Apr 24, 2017 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Large Cell Acanthoma

 Proliferation of atypical keratinocytes typically confined to basilar 1/3 of epidermis  Overlying parakeratosis and basilar budding usually seen • Solar lentigo (lentigo senilis)  Elongated, hyperpigmented rete ridges  Lacks keratinocyte atypia/pleomorphism • Seborrheic…

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