Toker Cell Hyperplasia

 Clinical history differs


– Generally affects unilateral nipple/areola in older adults


image Clear to pale cells with abundant cytoplasm scattered at all levels in epidermis

image Nuclear atypia present

– Hyperchromatic nuclei

– Prominent eosinophilic cytoplasm


image Variable mitotic activity


• Pagetoid dyskeratosis
image Clusters of somewhat pale or clear keratinocytes
– Slightly shrunken nuclei

– Perinuclear halo

image Possibly related to trauma

image Cells do not mark with CK7

• Clear cell papulosis
image Clinical presentation differs
– Child with multiple hypopigmented, white to flesh-colored papules on lower abdomen/groin area

image Scattered, benign-appearing cells in basal layer of acanthotic epidermis

image Cells stain with CK7

image
Toker Cell Hyperplasia
Toker cell hyperplasia is a rare histopathologic finding. Toker cells, a normal component of the nipple epithelium, are increased in number and may mimic Paget disease of the nipple.


image
Toker Cell Hyperplasia at Higher Magnification
At this magnification, the scattered, hyperplastic Toker cells in the epidermis mimic Paget disease of the nipple.

image
Toker Cell Hyperplasia at High Magnification
This is a high-magnification view of Toker cell hyperplasia. Toker cells image have bland nuclei with expanded, pale to clear-staining cytoplasm. They are in the basal and suprabasal layers of the epidermis.

image
Toker Cell Hyperplasia: CK7 Immunohistochemistry
In Toker cell hyperplasia, Toker cells are evident by light microscopy, and they are also highlighted by CK7 staining. The bland cells are scattered in the basal and suprabasal layers.


TERMINOLOGY


Definitions




• Increase in number of Toker cells in epidermis

• Absence of underlying ductal carcinoma

• Mimics Paget disease of nipple

• Awareness important to avoid overdiagnosis of Paget disease


CLINICAL ISSUES


Epidemiology




• Incidence
image Toker cells present by light microscopy in ~ 10% of normal nipples

image Toker cells also described in

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Apr 24, 2017 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Toker Cell Hyperplasia

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