Fibrillary Glomerulopathy Anthony Chang, MD Key Facts Clinical Issues Rare: < 1% of native kidney biopsies Associated with malignancy, dysproteinemia, and autoimmune disease Proteinuria (100%) Hematuria (˜ 50%) 40-50% progress…
Multilocular Cystic Nephroma Aleksandr Vasilyev, MD, PhD Key Facts Terminology Multilocular cystic nephroma (MCN) Cystic nephroma (CN), multilocular cyst Etiology/Pathogenesis Relationship to sex hormones is suggested Clinical Issues Female:male ratio…
Oculocerebrorenal Syndrome of Lowe Ami Bhalodia, MD Key Facts Terminology Oculocerebrorenal syndrome (OCRL) Etiology/Pathogenesis Inherited mutation caused by OCRL1 gene mutation Affects protein trafficking and cellular metabolism Clinical Issues X-linked…
Polyarteritis Nodosa Surya V. Seshan, MD Key Facts Terminology Necrotizing inflammation of medium-sized or small arteries without glomerulonephritis or vasculitis in arterioles, capillaries, or venules Clinical Issues HBV association in…
Sickle Cell Disease Anthony Chang, MD Key Facts Terminology Sickle cell nephropathy Etiology/Pathogenesis β-globin gene mutation Chromosome 11p15.5 Clinical Issues Presentation Chronic kidney disease Proteinuria Drugs Angiotensin-converting enzyme inhibitors Macroscopic…
Myeloma Cast Nephropathy Anthony Chang, MD Lynn D. Cornell, MD Key Facts Terminology Synonyms Light chain cast nephropathy Myeloma kidney Accumulation of monoclonal light chains may form casts (both cytotoxic…
Loin Pain Hematuria Syndrome Xin Gu, MD Key Facts Etiology/Pathogenesis Unknown or tubular obstruction from intranephron hemorrhage Clinical Issues LPHS is a diagnosis of exclusion Microscopic Pathology Normal or nonspecific…
Membranoproliferative Glomerulonephritis, Type I/III A. Brad Farris, III, MD Key Facts Terminology Subendothelial electron-dense deposits with mesangial interposition Clinical Issues Older children, adolescents, & young adults (˜ 7-30 years old)…
Aspergillosis Anthony Chang, MD Key Facts Etiology/Pathogenesis A. fumigatus A. flavus A. niger Clinical Issues Treatment Renal allograft nephrectomy Nephrostomy drainage and systemic antifungal therapy Voriconazole Incidence 0.1% in kidney…
Osmotic Tubulopathy Shane M. Meehan, MBBCh Key Facts Terminology Tubular epithelial swelling and isometric vacuolization, associated with exposure to parenteral carbohydrate solutions or contrast media, and acute kidney injury Etiology/Pathogenesis…
