Anthony Chang, MD

Hematoxylin & eosin shows a necrotic area of renal cortex with prominent neutrophilic inflammation and many acute angle branching hyphae image that are characteristic of Aspergillus.

Hematoxylin & eosin shows septate hyphae image with 45° angle branching, which has entirely replaced a glomerulus in an autopsied kidney of a patient with disseminated aspergillosis.



  • Aspergillus infection of kidney in immunosuppressed or immunocompromised patients


Environmental Exposure

  • Ubiquitous fungus in environment

Infectious Agents

  • Aspergillus

    • A. fumigatus

    • A. flavus

    • A. niger

    • A. terreus

    • A. nidulans



  • Incidence

    • 0.1% in kidney transplant patients after 1 year

  • Age

    • No age predilection

  • Gender

    • M:F = 4:1

  • Ethnicity

    • No ethnic predilection


  • Lungs

    • Most common site of involvement

  • Kidneys

    • 30-40% involvement in disseminated aspergillosis

    • Isolated involvement in some deceased donor kidney allografts

      • Probable transmission from deceased donor or during organ procurement

      • Fungi account for up to 2.5% of isolates cultured from perfusion solutions used for kidney preservation


  • Fever

  • Flank pain

  • Hematuria

Laboratory Tests

  • Serologic tests

    • Enzyme-linked immunoassay

      • Detection of galactomannan antigen of Aspergillus

    • Immunodiffusion

    • Complement fixation

  • Cultures

  • Direct microscopy

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Jul 7, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Aspergillosis
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