Includes neoplastic lesions previously classified as adenomas (both intestinal and pyloric types), papillary carcinoma in situ, papillomatosis Clinical Issues • Many patients asymptomatic, and ICPN discovered incidentally at cholecystectomy • Associated with…
2nd most common primary liver cancer after hepatocellular carcinoma Has been increasing around world, including USA Very prevalent in Asia, particularly in northeastern Thailand Equal frequency in men and women…
Mitoses > 20 in 10 HPF (based on count of at least 50 HPF; 1 HPF = 2 mm²), or Ki-67 labeling index > 20% based on at least 500…
Often accompanied by cholestasis • Vanishing bile duct syndrome Used to describe ductopenia related to drugs but not specific term Etiology/Pathogenesis • Many medication classes implicated Antiinflammatory, antibiotics, antiepileptics, psychiatric drugs, tranquilizers,…
Giant Cell TransformationH&E-stained section of a liver biopsy in a child with progressive familial intrahepatic cholestasis (PFIC) shows giant cell transformation of perivenular hepatocytes, typical of childhood cholestasis syndromes. Bland…
Results in different enzymatic defects in liver that are classified as glycogen storage disease (GSD) types 0, I, II, III, IV, VI, and IX Types I, III, and IX account…
Hepatitis C accounts for ∼ 20% of cases of acute hepatitis Clinical Issues • Symptoms generally mild or patients are asymptomatic Fulminant hepatic failure is rare • Most patients with acute hepatitis…
Evidence of genetic studies favors neoplastic process Likely from bone marrow-derived myeloid dendritic precursors Clinical Issues • Affects infants and children, rarely adults • Unisystem disease most often involves bone followed by…
Typically transmitted vertically, parenterally, or sexually Clinical Issues • 10% of infected patients become chronically infected 400 million people worldwide have chronic HBV • Symptoms include mild flu-like syndrome, nausea, vomiting, jaundice…
Portal vein thrombosis, systemic inflammatory conditions, some neoplasms such as renal cell carcinoma or lymphoma, artifactual sinusoidal dilatation • Other causes of parenchymal necrosis/hemorrhage Acetaminophen toxicity, ischemic liver injury Sinusoidal DilatationIn…
