Urothelial Carcinoma
Although for most cases, the distinction between urothelial carcinoma and poorly differentiated prostatic adenocarcinoma can be made on morphologic grounds, there is overlap in a minority of cases. Whereas usual…
Benign and Malignant Prostate following Treatment
Therapy with LHRH agonists and flutamide may result in three different histologic patterns in prostate cancer. The neoplastic acini may become atrophic (Fig. 14.2, eFigs. 14.6 to 14.12).4,7–13 At higher…
Inflammatory Conditions
Clinical prostatitis may give rise to elevated serum prostate-specific antigen (PSA) elevations.8 There are conflicting studies as to whether histologic evidence of either acute or chronic inflammation on biopsy correlates…
Emerging Biomarkers for Detection and Management of Prostate Carcinoma
Epigenetic Changes in Prostate Cancer Changes in DNA methylation marks, accompanied by epigenetic gene silencing, appear to be the earliest somatic genome changes in prostate cancer.21 New generation of assay…
Gross Anatomy and Normal Histology
The anterior fibromuscular stroma, which occupies approximately one-third of the prostate, contains very few glands and consists of smooth muscle tissue and dense fibrous tissue. The central zone forms a…
Reporting Cancer: Influence on Prognosis and Treatment
Currently, there is no consensus as to the optimal method for measuring tumor length or percentage of cancer on a core when there are two or more foci of prostate…
Mucinous Differentiation in the Benign and Malignant Prostate
Mucinous (colloid) adenocarcinoma of the prostate gland is one of the least common morphologic variants of prostatic carcinoma.5–7 A lack of precision in the definition of these mucinous neoplasms has…
