Fig. 4.1 Kidney and liver ALECT2 amyloidosis. Eosinophilic amyloid deposits in the kidney with glomerular, interstitial, and vascular involvement (a, H&E) stain with Congo red (b). Congo red stain viewed…
Fibril protein Precursor protein Systemic and/or localized Acquired or hereditary Target organs AL Immunoglobulin light chain S, L A, He All organs except CNS (Local AL amyloidosis may occur) AH…
Lymphoepithelioma-Like Carcinoma of the SkinHigh magnification of lymphoepithelioma-like carcinoma of the skin (LELCS) shows a prominent lymphohistiocytic infiltrate obscuring a background of large, undifferentiated epithelioid-appearing cells . Low Magnification of…
Gorlin-Goltz syndrome: Multiple cutaneous basal cell carcinomas, odontogenic keratocysts of jaw, palmar and plantar pits, rare medulloblastomas, and skeletal abnormalities • Rare cases not associated with NBCCS also reported Clinical Issues…
!DOCTYPE html> LYMPHOMAS AND HEMATOPOIETIC PROLIFERATIONS: LEUKEMIC AND NONLYMPHOID INFILTRATES Outline Chapter 198: Leukemia Cutis
!DOCTYPE html> EPIDERMAL TUMORS: PREMALIGNANT AND MALIGNANT EPIDERMAL TUMORS Outline Chapter 27: Actinic Keratosis Chapter 28: Actinic Cheilitis Chapter 29: Squamous Cell Carcinoma In Situ (Bowen Disease)
Range: 0.3-6.5 cm Microscopic • Well circumscribed and lobulated • Mostly composed of mature hyaline cartilage • Variable amounts of calcification • Ossification common • Granulomatous inflammation in 15% of cases • Rare tumors with extensive…
Considered to fall on morphologic spectrum with myopericytoma, myofibroma, and angioleiomyoma Clinical Issues • Most common in young adults (20-40 years) • Female predilection in subungual tumors • Most common in distal extremities…
Cells are markedly enlarged and atypical to bizarre-appearing Top Differential Diagnoses • Melanoma in situ, superficial spreading type • Melanoma in situ, lentigo maligna type • Atypical (dysplastic) junctional melanocytic nevus • Irritated/traumatized nevi…
