Therapy with LHRH agonists and flutamide may result in three different histologic patterns in prostate cancer. The neoplastic acini may become atrophic (Fig. 14.2, eFigs. 14.6 to 14.12).4,7–13 At higher…
Clinical prostatitis may give rise to elevated serum prostate-specific antigen (PSA) elevations.8 There are conflicting studies as to whether histologic evidence of either acute or chronic inflammation on biopsy correlates…
Epigenetic Changes in Prostate Cancer Changes in DNA methylation marks, accompanied by epigenetic gene silencing, appear to be the earliest somatic genome changes in prostate cancer.21 New generation of assay…
The anterior fibromuscular stroma, which occupies approximately one-third of the prostate, contains very few glands and consists of smooth muscle tissue and dense fibrous tissue. The central zone forms a…
Currently, there is no consensus as to the optimal method for measuring tumor length or percentage of cancer on a core when there are two or more foci of prostate…
Mucinous (colloid) adenocarcinoma of the prostate gland is one of the least common morphologic variants of prostatic carcinoma.5–7 A lack of precision in the definition of these mucinous neoplasms has…
Fig. 40.1 Upper panel illustrates a middle-aged man with IgA vasculitis, nephrotic syndrome, and renal failure. Note that some purpuric plaques are centrally ulcerated. Lower panel illustrates a middle-aged woman…
