It is a report of the insoluble substances that went into the reactor (i.e., the anatomically well-defined defect) and the insoluble products that were eventually synthesized in it. Reaction diagram…

Fig. 8.1 Wounds close partly by contraction and regeneration in the tadpole; however, they close by contraction and scar formation in the adult frog. Photos of healing of full-thickness excisional…

In this example, the large difference in magnitude between the time constants suggests that the two processes (i.e., the developmental transition in healing outcome and the healing process) occur at…

Protein Method Units Collagen scaffold tube Silicone tube TGFβ1 ELISA ng protein per g tissue 43.6 ± 1.8 65.2 ± 4.9 TGFβ1 WB a.u. 1.29 ± 0.34 1.78 ± 0.66 TGFβ2 WB a.u. 0.78 ± 0.26 0.93 ± 0.37 TGFβ3 WB a.u….

Fig. 5.1 Structure of the intact basement membrane in skin. Top: Electron micrograph showing the two major layers comprising the basement membrane, lamina lucida (LL) and lamina densa (LD), that…

Fig. 2.1 The epidermis is a regenerative tissue. Following controlled injury (stripping or blistering), which leaves the dermis intact (left), the epidermis recovers its structure completely at the site of…

Fig. 6.1 (Top; a): Construction of the characteristic curve for a silicone tube used as a bridge for a gap of variable length in the mouse (left) and rat (right)…

Fig. 1.1 Amputation of newt limbs leads to spontaneous regeneration. Limbs were amputated either below (left) or above the elbow (right) and were photographed at the indicated times while regenerating….

Fig. 10.1 A scaffold with regenerative activity was initially synthesized as a highly porous graft copolymer of type I collagen and chondroitin 6-sulfate (GAG). It was modified later by omitting…

Fig. 3.1 Selection of an anatomically well-defined defect for study of induced skin regeneration. Top left: Incision through the entire dermis. Top right: The epidermis has been removed but the…