Sinonasal Hemangiopericytoma
Sinonasal Hemangiopericytoma Jonathan B. McHugh, MD Key Facts Clinical Issues Accounts for < 0.5% of sinonasal neoplasms Peak incidence in 6th-7th decades Most frequently involve nasal cavity Excellent overall 5-year…
Spindle Cell Rhabdomyosarcoma
Spindle Cell Rhabdomyosarcoma Khin Thway, BSc, MBBS, FRCPath Key Facts Terminology Uncommon subtype of rhabdomyosarcoma occurring in both children and adults; composed of largely cellular proliferation of predominantly spindled cells…
Embryonal Rhabdomyosarcoma
Embryonal Rhabdomyosarcoma Khin Thway, BSc, MBBS, FRCPath Key Facts Terminology Malignant soft tissue tumor that shows variable differentiation toward skeletal muscle Encompasses botryoid, spindle cell, and anaplastic variants Clinical Issues…
Pleomorphic Rhabdomyosarcoma
Pleomorphic Rhabdomyosarcoma Khin Thway, BSc, MBBS, FRCPath Key Facts Terminology High-grade sarcoma occurring almost exclusively in adults and displaying evidence of skeletal muscle differentiation Diagnosis requires identification of pleomorphic rhabdomyoblasts…
Congenital Smooth Muscle Hamartoma
Congenital Smooth Muscle Hamartoma Steven D. Billings, MD Key Facts Terminology Rare lesion presenting in infants, characterized by disorganized proliferation of benign smooth muscle bundles in dermis, often involving subcutis…
Protocol for the Examination of Rhabdomyosarcoma Specimens
Protocol for the Examination of Rhabdomyosarcoma Specimens Rhabdomyosarcoma and Related Neoplasms: Resection or Biopsy Surgical Pathology Cancer Case Summary (Checklist) Procedure ____Biopsy ____Excision, local ____Excision, radical ____Excision, compartmentectomy Amputation (specify…
Myopericytoma
Myopericytoma Thomas Mentzel, MD Key Facts Terminology Benign perivascular neoplasm composed of perivascular myoid tumor cells (myopericytes) Myopericytoma forms morphologic spectrum with angioleiomyoma, myofibroma, glomus tumor, and so-called hemangiopericytoma Clinical…
Rhabdomyoma
Rhabdomyoma Cyril Fisher, MD, DSc, FRCPath Key Facts Terminology Benign tumor with skeletal muscle differentiation Extracardiac tumors can be of adult or fetal histologic type Etiology/Pathogenesis Some fetal rhabdomyomas associated…
Glomus Tumors
Glomus Tumors Thomas Mentzel, MD Key Facts Terminology Perivascular myogenic mesenchymal neoplasm composed of cells closely resembling smooth muscle cells of normal glomus body Clinical Issues Distal extremities, especially in…
Neuroblastoma and Ganglioneuroblastoma
Neuroblastoma and Ganglioneuroblastoma Jessica Comstock, MD Cyril Fisher, MD, DSc, FRCPath Key Facts Terminology Malignant tumor derived from primordial neural crest cells Clinical Issues 3rd most common malignant tumor in…
