Pleomorphic Rhabdomyosarcoma

Pleomorphic Rhabdomyosarcoma

Khin Thway, BSc, MBBS, FRCPath

Pleomorphic rhabdomyosarcoma is shown with sheets of markedly anaplastic, frequently bizarre image or multinucleate image polygonal cells. The morphology is indistinguishable from other pleomorphic tumors.

In this specimen, the tumor shows a fascicular architecture with bundles of atypical spindle cells with vesicular or hyperchromatic nuclei.



  • High-grade sarcoma occurring almost exclusively in adults and displaying evidence of skeletal muscle differentiation

  • Diagnosis requires identification of pleomorphic rhabdomyoblasts and expression of skeletal muscle specific immunohistochemical markers



  • Age

    • Older adults

      • Median: 6th decade

    • Very rare cases reported in children and adolescents

  • Gender

    • M>F

Jul 9, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Pleomorphic Rhabdomyosarcoma
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