Local recurrences Metastases Microscopic • Epithelial islands with interspersed glands/ducts • Cells composing islands are variable Clear Poroid Squamoid (less common) Rarely mucinous • Hyalinized stroma Similar to hidradenoma • Infiltrative growth pattern Not…
Composed of enlarged cells with abundant clear to vacuolated-appearing cytoplasm • Chondroid melanoma Malignant epithelioid cells associated with prominent myxochondroid-appearing matrix • Osteoid melanoma Malignant epithelioid cells associated with prominent osteoid-appearing material…
Conjunctival Melanoma Presenting as Pigmented PatchClinical image shows an expansile pigmented patch at the limbus and adjacent to the iris . Bulbar conjunctiva close to the limbus is the most…
Embryonal, alveolar, pleomorphic, and epithelioid types of RMS have been described as primary cutaneous tumors Clinical Issues • Very rare Cutaneous metastases or secondary involvement of skin by deep primary must…
Clinical PhotographPhotograph shows a medium-sized infantile hemangioma on the face of a female infant. Most of these lesions are located in the head and neck region. (Courtesy J. Hall, MD.)…
Conjunctival Nevus With Prominent Epithelial CystsConjunctival melanocytic nevi (50%) can exhibit numerous epithelial-lined cysts located within the lesion, as seen here under scanning magnification. This is a useful finding, supporting…
Primarily solid Primarily cystic Solid and cystic • Classically, does not connect to epidermis and is deep-seated • Solid areas composed of varying proportion of Clear cells Poroid cells Squamoid cells Rarely…
Clinical Photograph of PoromaClinical photograph shows a traumatized poroma on the lower back of an adult male, which presented as an irritated polypoid lesion. Poroma With Squamoid FeaturesLow magnification of…
Typically show hyperchromatic-staining nuclei with small nucleoli Cytoplasm with prominent melanin pigmentation • Atypical Reed nevus Often larger, more cellular lesions Increased mitotic activity, especially in junctional component Top Differential Diagnoses…
