Xanthelasma, eruptive, tuberous, tendinous, planar, plexiform Etiology/Pathogenesis • Associated with hereditary lipoproteinemias and occasionally secondary lipoproteinemias • May also occur in normolipemic patients Particularly plexiform xanthoma Clinical Issues • Wide age range (children…
May be difficult to identify, especially if desmoplastic type or heavily inflamed Papular Growth in Pigmented PatchThe marked area , prior to biopsy, shows a papular growth in an ill-defined…
Usually on extremities • Angiokeratoma of Fordyce Elderly men Multiple lesions, often on scrotum • Angiokeratoma of Mibelli Childhood Warty lesions over bony prominences of acral locations • Angiokeratoma corporis diffusum Associated with…
Pretibial skin also common Uncommon on face • Benign but up to 50% recur • Rare intraoral, orbital, intradural, and paraspinal cases Microscopic • Multiple lobules with abundant myxoid matrix • Well-defined lobular architecture…
Associated with low recurrence and metastatic rates Microscopic • Multinodular solid or cystic tumor based in dermis • Solid areas composed of dense collections of cells with focal ductal lumina • Cystic/glandular areas…
Localized, wart-like variants, solitary or multiple • Nevus unius lateris Long, linear lesions on unilateral extremities • Ichthyosis hystrix Large, bilateral lesions on trunk Etiology/Pathogenesis • Epidermal nevus syndrome includes neurological, ocular, and…
Juvenile XanthogranulomaThis is a typical appearance of a juvenile xanthogranuloma removed from the face of a small boy. The lesion is uniform and cellular and proliferates in the dermis with…
Cystic areas resembling infundibulum with stratified squamous epithelium, granular layer, and basket-weave stratum corneum Areas resembling internal and external root sheath Foci of matrical epithelium Areas resembling hair bulb with…
Cells characteristically cluster around thin-walled capillaries • In postmenopausal patients, cells are more spindled, and overall cellularity is low • Mature adipose tissue component in minority of cases • Some cases show morphologic…
Subset have brisk mitotic activity (> 5/10 HPF in 20%; > 10/10 HPF in 5%) Atypical mitotic figures may be seen Ancillary Tests • Often positive for variety of nonspecific markers,…
