a.k.a. NAME (nevi, atrial myxomas, myxoid neurofibromas, and ephelides) and LAMB (lentigines, atrial myxomas, and blue nevi) syndromes If patient has multiple cutaneous myxomas, should consider Carney complex Clinical Issues…
Less commonly: Lateral, thyroid, or subcutaneous • M:F = 4:1 • Presents with airway compression, dysphagia, or infection, or may be asymptomatic • Complete surgical excision is treatment of choice • Excellent long-term clinical…
May also represent later stage/regressing variant of trichofolliculoma, but is typically dermal-based tumor with prominent sebaceous glands • Dilated pore of Winer Cystically dilated follicle that communicates with overlying epidermis • Trichoepithelioma…
Predominantly composed of atypical squamous cells, with scattered melanocytes – Melanocytes Of low density Single, not nested Dendritic shaped Nuclei not atypical • Pseudoepitheliomatous hyperplasia associated with malignant melanoma Keratinocytes in hyperplastic…
More common in children • Composite hemangioendothelioma (HE) Composed of at least 2 distinct HE types • Kaposi sarcoma • Angiosarcoma Retiform Hemangioendothelioma at Low MagnificationLow-magnification examination of a retiform hemangioendothelioma (RHE) shows…
SCR presents as single papular or nodular cutaneous lesion GCR is characterized by eruption of multiple small cutaneous lesions • Juvenile xanthogranuloma Typically single lesion occurring in children but can be…
Evidence of apocrine glandular differentiation • Aggressive digital papillary adenocarcinoma Larger nodular tumor with ductal structures More cellular and shows infiltrative features • Metastatic adenocarcinoma Cytologic atypia and mitoses usually prominent Diagnostic…
Clinical history differs – Generally affects unilateral nipple/areola in older adults Clear to pale cells with abundant cytoplasm scattered at all levels in epidermis Nuclear atypia present – Hyperchromatic nuclei – Prominent eosinophilic…
Superficial telangiectatic vessels often present May be associated with mild chronic inflammation • Increased fibroblasts, lymphocytes, and mast cells usually present Top Differential Diagnoses • Hypertrophic scar Lacks characteristic hyalinized collagen bundles…
Parameatal cyst, paraurethral cyst, genitoperineal cyst, mucoid cyst • Midline developmental cyst found at any point from external urethral meatus to anus Etiology/Pathogenesis • Defective embryological closure of median raphe Abnormal closure…
