Pharmacology of Cardiac Contractility Ehrin J. Armstrong INTRODUCTION & CASE PHYSIOLOGY OF CARDIAC CONTRACTION Myocyte Anatomy Myocyte Contraction Regulation of Contractility The Sodium Pump and Sodium–Calcium Exchange Calcium Storage and…
Pharmacology of Dopaminergic Neurotransmission David G. Standaert and Victor W. Sung INTRODUCTION & CASE BIOCHEMISTRY AND CELL BIOLOGY OF DOPAMINERGIC NEUROTRANSMISSION Dopamine Storage, Release, Reuptake, and Inactivation Dopamine Receptors Central…
Pharmacology of the Adrenal Cortex Rajesh Garg and Gail K. Adler INTRODUCTION & CASE OVERVIEW OF THE ADRENAL CORTEX GLUCOCORTICOIDS Physiology Synthesis Metabolism Physiologic Actions Regulation Pathophysiology Adrenal Insufficiency Glucocorticoid…
INTRODUCTION This chapter reviews the physiology and pharmacology of insulin, glucagon, and the other major hormones that regulate glucose homeostasis. Diabetes mellitus is clinically the most common disease of these…
2 Pharmacodynamics Quentin J. Baca and David E. Golan INTRODUCTION & CASE DRUG–RECEPTOR BINDING DOSE–RESPONSE RELATIONSHIPS Graded Dose–Response Relationships Quantal Dose–Response Relationships DRUG–RECEPTOR INTERACTIONS Agonists Antagonists Competitive Receptor Antagonists Noncompetitive…
INTRODUCTION In 1928, Alexander Fleming made a chance discovery that would revolutionize the treatment of bacterial infections. He observed that certain molds produce a compound that inhibits the growth of…
INTRODUCTION While infectious diseases and cancers have different underlying etiologies, from a pharmacologic perspective, the broad principles of treatment are similar. One common thread in these pharmacologic strategies is the…
Drug–Receptor Interactions Francis J. Alenghat and David E. Golan INTRODUCTION & CASE CONFORMATION AND CHEMISTRY OF DRUGS AND RECEPTORS Impact of Drug Binding on the Receptor Membrane Effects on Drug–Receptor…
Integrative Inflammation Pharmacology: Peptic Ulcer Disease Dalia S. Nagel and Helen M. Shields INTRODUCTION & CASES 1 & 2 PHYSIOLOGY OF GASTRIC ACID SECRETION Neurohormonal Control of Gastric Acid Secretion…
Pharmacology of Analgesia Robert S. Griffin and Clifford J. Woolf INTRODUCTION & CASE PHYSIOLOGY Sensory Transduction: Excitation of Primary Afferent Neurons Conduction from the Periphery to the Spinal Cord Transmission…
