T-Cell Neoplasms
T-Cell Neoplasms Diane C. Farhi The T-cell neoplasms are relatively rare compared to B-cell neoplasms, but they nevertheless consist of many different entities. In this chapter, we have included the…
Plasma Cell and Related Neoplasms
Plasma Cell and Related Neoplasms Diane C. Farhi Plasma cell neoplasms comprise a wide spectrum of disease (Tables 25.1 and 25.2). The entities discussed below differ widely in clinical presentation,…
Hodgkin Lymphoma
Hodgkin Lymphoma Diane C. Farhi GENERAL FEATURES Hodgkin lymphoma (HL) is a B-cell neoplasm characterized by neoplastic cells—Reed-Sternberg cells and their variants—in a prominent inflammatory and fibrous background (1, 2,…
B-Cell Neoplasms
B-Cell Neoplasms Diane C. Farhi B-cell neoplasms are a heterogeneous group of clinicopathologic entities, ranging from indolent to highly aggressive (Table 23.1). Those composed predominantly of mature small B-cells may…
Histiocytic Dendritic Cell and Neoplasms
Histiocytic Dendritic Cell and Neoplasms Diane C. Farhi Tumors of dendritic cells and histiocytes have been recently reclassified (2008) by the World Health Organization (WHO) (Table 22.1; see Appendix A…
Myeloproliferative and Related Neoplasms
Myeloproliferative and Related Neoplasms Diane C. Farhi GENERAL FEATURES Definition and Classification Myeloproliferative neoplasms (MPN) are primarily characterized by increased peripheral blood cell counts, increased bone marrow cellularity, and preservation…
Myelodysplastic Syndromes
Myelodysplastic Syndromes Diane C. Farhi GENERAL FEATURES Definition and Classification Myelodysplastic syndromes (MDS) are a group of clonal disorders of hematopoietic stem cells, characterized by dysplastic morphology, cytogenetic aberrations, and—in…
Precursor Lymphoid Neoplasms
Precursor Lymphoid Neoplasms Diane C. Farhi GENERAL FEATURES Nomenclature New precursor lymphoid neoplasms include “solid” tumors or lymphoblastic lymphoma, and “liquid” tumors or acute lymphoblastic leukemia (ALL). Lymphoblastic lymphoma may…
Acute Myeloid Leukemia
Acute Myeloid Leukemia Diane C. Farhi GENERAL FEATURES Nomenclature Acute leukemia arising from myeloid cells has been variously referred to as myeloblastic, myelocytic, and myeloid, with little, if any, clarification…
Effects of Therapy
Effects of Therapy Diane C. Farhi Numerous therapeutic agents are used in treating hematolymphoid disorders, and their effects are diverse. This section focuses on morphologic changes observed in the peripheral…
