Endocannabinoid System: a Brief Primer
THE ENDOCANNABINOID SYSTEM: A BRIEF PRIMER Humans have used cannabis for centuries, but only in the last 50 years or so has any scientific understanding emerged as to how cannabis…
Medical Cannabis Does and Doesn’t Work
HOW MEDICAL CANNABIS DOES AND DOESN’T WORK According to a recent survey by the International Association for Cannabinoid Medicines (IACM), most individuals who use cannabis for medical reasons are seeking…
High-performance liquid chromatography
12 High-performance liquid chromatography Keypoints Introduction Instrumentation Stationary and mobile phases Structural factors which govern rate of elution of compounds from HPLC columns Elution of neutral compounds Control of elution…
Physical and chemical properties of drug molecules
2 Physical and chemical properties of drug molecules Introduction Calculation of pH value of aqueous solutions of strong and weak acids and bases Dissociation of water Strong acids and bases…
Mass spectrometry
9 Mass spectrometry Keypoints Introduction Ion generation Electrospray ionisation (ESI) Atmospheric pressure chemical ionisation (APCI) Electron impact ionisation (EI) Matrix assisted laser desorption ionisation (MALDI) Other ionisation methods Ion separation…
Nuclear magnetic resonance spectroscopy
8 Nuclear magnetic resonance spectroscopy Keypoints Introduction Instrumentation Proton (1H) NMR Chemical shifts Integration and equivalence Multiplicity and spin–spin coupling Splitting diagrams and spin systems Application of NMR to structure…
Gas chromatography
11 Gas chromatography Keypoints Introduction Instrumentation Syringes Injection systems GC oven Types of column Selectivity of liquid stationary phases Kovats indices and column polarity Examples of the separation of mixtures…
Titrimetric and chemical analysis methods
3 Titrimetric and chemical analysis methods Keypoints Introduction Instrumentation and reagents Glassware Primary standards and standard solutions Direct acid/base titrations in the aqueous phase Strong acid/strong base titrations Weak acid/strong…
Infrared spectrophotometry
5 Infrared spectrophotometry Keypoints Introduction Factors determining intensity and energy level of absorption in IR spectra Intensity of absorption Energy level of absorption Instrumentation Instrument calibration Sample preparation Application of…
Ultraviolet and visible spectroscopy
4 Ultraviolet and visible spectroscopy Keypoints Introduction Factors governing absorption of radiation in the UV/visible region Beer–Lambert Law Instrumentation Diode array instruments Instrument calibration Calibration of absorbance scale Calibration of…
