Molecular Pathology Techniques
Fig. 3.1 Examples of FISH applications in molecular neuropathology: (a–c) 1p evaluation, 1p red, 1q green: (a) Maintenance of 1p (2:2 signals), (b) 1p loss (1:2 signals), (c) relative deletions/superloss…
Pediatric High-Grade Gliomas and DIPG
Fig. 7.1 Pediatric glioblastoma exhibiting pseudopalisading necrosis. Hematoxylin and eosin staining of a Grade IV GBM (40× magnification). Arrows point to pseudopalisading necrosis Anaplastic astrocytomas differ from anaplastic oligodendrogliomas by…
Adult High-Grade (Diffuse) Glioma
Histology N % of all tumors Median age Rate (95 % CI) Glioblastoma 49,088 15.8 64 3.19 (3.16–3.22) Anaplastic astrocytoma 5,374 1.7 54 0.36 (0.35–0.37) Anaplastic oligodendroglioma 1,687 0.5 49…
Hemangioblastoma
Fig. 14.1 (a, b) H&E, (c) ERG, (d) Inhibin, (e) Carbomic anhydrase and (f) Azocarmine. (a) H&E stain shows a highly vascular neoplasm. The tumor is composed of vascular cells…
Brain Tumor Stem Cells
Fig. 2.1 Properties of stem cells. Stem cells have the ability to self-renew and differentiate to a mature cell through an intermediate progenitor. The ability to give rise to cells…
Ependymoma
Fig. 5.1 Molecular subgroups of posterior fossa ependymoma, as described by Witt et al., Wani et al., and Johnson et al. Group A, Group 1, and clusters G, H, and…
