Gastrointestinal Infections
Antibiotic Resistance gene Nucleotide change Amino acid change Clarithromycin 23S rRNA A2142G NA A2143G NA Ciprofloxacin gyrA C(T) to A N87K C(T) to G N87K A to G D91G G…
Bacterial Infections
Figure 49.1 Schematic of MALDI-TOF mass spectrometry for differentiation of two organisms (A and B). Differences in DNA (1) encode for different protein products (2) which are differentially fragmented under…
Viral Infections of the Central Nervous System
Herpesviruses Herpes simplex 1 and 2 Varicella-zoster Epstein-Barr Cytomegalovirus Human herpesvirus 6 Enteroviruses Poliovirus Coxsackievirus Echovirus Numbered enteroviruses Parechoviruses Human parechovirus 1–14 Arboviruses See Table 48.2 Childhood illness associated Measles…
Viral Infections in Transplant Recipients
Clinical use General assay characteristics Specific clinical applications Diagnosis Rapid turnaround time thereby facilitating targeted antiviral therapy Highly specific for the pathogen of interest More sensitive than conventional methods such…
Human Immunodeficiency Virus Type 1
Test Method Target Specimen volume a Range Amplicor HIV-1 Monitor® version 1.5 (Roche Diagnostics Indianapolis, IN) RT-PCR HIV-1 gag gene Standard 200 μl 400–750,000 copies/mL Ultrasensitive 500 μl 50–100,000 copies/mL…
Host Factor Pharmacogenetics for Treatment of Infectious Diseases
Figure 20.1 Proposed mechanism for HLA-B*5701 abacavir hypersensitivity Australia was one of the earliest countries to introduce routine HLA-B*5701 screening and results from the prospective study that was conducted between…
Breast Cancer
© Springer International Publishing Switzerland 2016Debra G.B. Leonard (ed.)Molecular Pathology in Clinical Practice10.1007/978-3-319-19674-9_33 33. Breast Cancer Carolyn Mies1 (1) Genomic Health Inc., 301 Penobscot Drive, Redwood City, CA 94063, USA Carolyn Mies Email: cmies@genomichealth.com Abstract…
Hereditary Paraganglioma and Pheochromocytoma
Gene Study 1 (%) Study 2 (%) Study 3 a (%) SDHB 16 (8.4) 24 (4.8) 38 (24.7) SDHC 2 (1.1) 4 (0.8) 2 (1.3) SDHD 3 (1.6) 47 (9.4)…
Hereditary Skin Cancer
Skin cancer type Associated syndromes Cutaneous basal cell carcinoma Basal cell nevus syndrome (BCNS) Bazex syndrome Rombo syndrome Brooke-Spiegler syndrome Muir-Torre syndrome Xeroderma pigmentosum Squamous cell carcinoma Xeroderma pigmentosum Ferguson-Smith…
