Cutaneous Gamma-Delta T-Cell Lymphoma

Apr 24, 2017 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Cutaneous Gamma-Delta T-Cell Lymphoma

 Malignant T cells rim around adipocytes  Prominent karyorrhexis/apoptosis and angioinvasion Ancillary Tests • Immunohistochemistry: TCRδ1(+), βF1(-), CD56(+), CD4(-), CD8(-) • EBER(-), cytotoxic markers (+) • T-cell receptor gene rearrangement Top Differential Diagnoses • Subcutaneous…

read more

Leiomyoma (Pilar)

Apr 24, 2017 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Leiomyoma (Pilar)

 Pilar type (piloleiomyoma) arises from arrector pili  Genital type arises from specialized genital smooth muscle Etiology/Pathogenesis • Hereditary leiomyomatosis and renal cell cancer syndrome  Multiple leiomyomas of skin and uterus  Subset…

read more

Neuromas

Apr 24, 2017 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Neuromas

 Solitary circumscribed neuroma (“palisaded encapsulated neuroma”) represents spontaneous proliferation of peripheral nerve fibers  Multiple mucosal neuromas associated with multiple endocrine neoplasia syndrome (type 2B) represents rare autosomal dominant condition  Traumatic…

read more

Myxoinflammatory Fibroblastic Sarcoma

Apr 24, 2017 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Myxoinflammatory Fibroblastic Sarcoma

 Inflammatory component shows variable mixtures of lymphoplasmacytic cells, eosinophils, neutrophils, and histiocytes • Areas with prominent myxoid change • Scattered enlarged atypical tumor cells, some with macronucleoli  Cells with macronucleoli resemble Reed-Sternberg…

read more

Penile and Vulvar Intraepithelial Neoplasia

Apr 24, 2017 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Penile and Vulvar Intraepithelial Neoplasia

 Elongated and anastomosing rete ridges  Atypical basal cells with hyperchromatic-staining nuclei  Subtle abnormal maturation (large, eosinophilic keratinocytes)  Whorling and keratin pearl formation  Usually associated with LS&A  Preferential association with HPV-unrelated…

read more

Metastatic Skin Tumors

Apr 24, 2017 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Metastatic Skin Tumors

 Skin metastases: Nodule, often pigmented, may be ulcerated, multiple or solitary  Nodal metastases: Usually in regional lymph nodes  Blue nevus-like melanoma: Blue macule/papule, often near original site of primary melanoma…

read more

Basal Cell Carcinoma

Apr 24, 2017 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Basal Cell Carcinoma

 Genes implicated include PTCH1 (Gorlin syndrome),  TP53, SOX9, BMI1, BAX, RMRP Clinical Issues • Extremely common: Most common cancer in humans • Most common in head and neck region (up to…

read more

Oral Melanoma

Apr 24, 2017 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Oral Melanoma

 Represent < 0.5% of all oral malignancies • Mean in 6th-7th decades • M > F (2.5-3:1) • Hard palate and maxillary alveolus are most common sites of involvement (~ 80%) • Cervical lymph…

read more
Premium Wordpress Themes by UFO Themes