Spindle Cell/Pleomorphic Lipoma

Apr 24, 2017 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Spindle Cell/Pleomorphic Lipoma

 Variable admixture of bland spindle cells, ropey collagen, mature adipose tissue, myxoid stroma, and mast cells • PL contains multinucleated tumor cells • Morphologic variants: Fat-free, fat-poor, angiomatous Ancillary Tests • CD34(+); loss…

read more

Adult T-Cell Leukemia/Lymphoma

Apr 24, 2017 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Adult T-Cell Leukemia/Lymphoma

 Epidermotropism &/or Pautrier microabscesses • Peripheral blood with multilobated “flower cells” • Lymph nodes with effaced architecture & diffuse infiltrate • Bone marrow with patchy involvement & increased osteoclasts Ancillary Tests • Confirmation of…

read more

Trichoblastoma

Apr 24, 2017 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Trichoblastoma

 Can be multiple in some cases • Rare recurrences and association with, or progression to, malignancy [basal cell carcinoma (BCC)] Macroscopic • Nodular lesion involving deep dermis and subcutis • Large, typically >…

read more

Condyloma Acuminatum (Genital Wart)

Apr 24, 2017 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Condyloma Acuminatum (Genital Wart)

 Irregular wrinkled nuclei  Bi- and multinucleation  Perinuclear vacuolization • Old lesions may mimic seborrheic keratoses Ancillary Tests • Immunostain for p16 is negative (there is no overexpression) • In situ hybridization and PCR…

read more

Granular Cell Tumor

Apr 24, 2017 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Granular Cell Tumor

 Female predilection  More prevalent in African Americans • Wide anatomic distribution, usually arises in skin and subcutaneous tissue  Head and neck region common (tongue, oral cavity) • Usually solitary, painless nodule, plaque,…

read more

Leiomyosarcoma

Apr 24, 2017 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Leiomyosarcoma

 Lesions restricted to cutis only rarely metastasize Microscopic • Perpendicularly oriented fascicles of spindle cells • Brightly eosinophilic cytoplasm • Blunt-ended nuclei • Nuclear atypia and mitoses Ancillary Tests • Labels as per smooth muscle:…

read more

Acral Lentiginous Melanoma

Apr 24, 2017 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Acral Lentiginous Melanoma

 Rare to absent in early lesions, prominent and confluent in late lesions  Nests are irregular in size and shape, randomly alternate with single melanocytes • Cells show elongated, ovoid hyperchromatic nuclei…

read more

Desmoplastic Melanoma

Apr 24, 2017 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Desmoplastic Melanoma

 HMWCKs(+), p63; S100(-) • Atypical fibroxanthoma  S100(-); CD10/CD68/CD99 (+) • Dermatofibroma: FXIIIA/CD10 (+); S100(-) • Dermatofibrosarcoma protuberans: CD34(+); S100(-) • Neural tumors  S100/SOX10 (+); CD34(+) (not in DM) • Leiomyosarcoma  Actin/desmin (+), S100(-) Scar-Like Appearance…

read more
Premium Wordpress Themes by UFO Themes