Primary Cutaneous Follicle Center Lymphoma
Primary Cutaneous Follicle Center Lymphoma Aaron Auerbach, MD, PhD Key Facts Terminology PCFCL Mature B-cell lymphoma of follicle center cells, primary to skin and not originating in another anatomic site…
Diffuse Large B-cell Lymphoma, Leg Type
Diffuse Large B-cell Lymphoma, Leg Type Sa A. Wang, MD Key Facts Terminology Primary cutaneous DLBCL composed exclusively of large transformed cells Clinical Issues 20% of primary cutaneous B-cell lymphomas…
Intravascular Large B-cell Lymphoma
Intravascular Large B-cell Lymphoma Francisco Vega, MD, PhD Key Facts Terminology Rare large B-cell lymphoma characterized by selective intravascular growth Clinical Issues Heterogeneous clinical signs: Nodules/plaques (49%), macules (23%), telangiectatic…
Histiocytic Sarcoma
Histiocytic Sarcoma Aaron Auerbach, MD, PhD Key Facts Terminology Histiocytic sarcoma (HS) Malignant histiocytosis Extramedullary monocytic tumor Clinical Issues Extremely rare tumor Mostly seen in adults Usually rash or single…
Non-Langerhans Cell Histiocytoses
Non-Langerhans Cell Histiocytoses Aaron Auerbach, MD, PhD Key Facts Terminology Wide range of histiocytic disorders that are not derived from Langerhans cells Sometimes difficult to categorize because of overlapping morphologic…
Cutaneous Plasmacytoma
Cutaneous Plasmacytoma Aaron Auerbach, MD, PhD David Cassarino, MD, PhD Key Facts Terminology Neoplasm of monoclonal plasma cells Must 1st rule out plasmacytoid B-cell lymphoma Clinical Issues Skin is rare…
Polyvinylpyrrolidone Storage Disease
Polyvinylpyrrolidone Storage Disease Cyril Fisher, MD, DSc, FRCPath Key Facts Etiology/Pathogenesis Phagocytic foreign body-type reactive condition Found in aerosol hair sprays, adhesives, lithographic solutions, shaving products, plastics Used to improve…
Rosai-Dorfman Disease
Rosai-Dorfman Disease Elizabeth A. Montgomery, MD Key Facts Terminology Lesional histiocytes contain variable numbers of intact lymphocytes within their cytoplasm Referred to as lymphophagocytosis or emperipolesis Sinus histiocytosis with massive…
Multicentric Reticulohistiocytosis
Multicentric Reticulohistiocytosis David Cassarino, MD, PhD Key Facts Terminology Giant cell reticulohistiocytosis Clinical Issues Most cases occur in adults > 40 years old Multiple nodules and arthropathy Prognosis is variable;…
Reticulohistiocytoma
Reticulohistiocytoma David Cassarino, MD, PhD Key Facts Terminology Proliferation of histiocytes with abundant dense, glassy-appearing eosinophilic cytoplasm Clinical Issues Usually occurs in adults > 40 years old, but cases have…
