Multicentric Reticulohistiocytosis

Multicentric Reticulohistiocytosis

David Cassarino, MD, PhD

Low magnification of MCR shows a nodular proliferation of enlarged histiocytic cells in the dermis. There is a very thin grenz zone image, and the epidermis shows flattening of the rete ridges.

Higher magnification of MCR shows a proliferation of numerous enlarged histiocytic-appearing cells image associated with a background mixed inflammatory infiltrate containing scattered eosinophils image.



  • Multicentric reticulohistiocytosis (MCR)


  • Giant cell reticulohistiocytosis

  • Reticulohistiocytosis of skin and synovia


  • Proliferation of large histiocytes with dense eosinophilic cytoplasm involving multiple organs

Jul 8, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Multicentric Reticulohistiocytosis

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