Polyvinylpyrrolidone Storage Disease

Polyvinylpyrrolidone Storage Disease

Cyril Fisher, MD, DSc, FRCPath

Low-magnification image of PVP storage disease shows soft tissue infiltrated by sheets and nests of uniform macrophages containing basophilic material in their cytoplasm.

Higher magnification shows histiocytic infiltrate with “bubbly” basophilic cytoplasm containing PVP and circular spaces image. The nuclei image are small and lack atypia and mitotic activity.



  • Polyvinylpyrrolidone (PVP) storage disease


  • Mucicarminophilic histiocytosis

  • Polyvinylpyrrolidone granuloma


  • Phagocytic foreign body-type reactive condition in which PVP is deposited and retained in tissue

Jul 8, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Polyvinylpyrrolidone Storage Disease
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