Intravascular Large B-cell Lymphoma

Intravascular Large B-cell Lymphoma

Francisco Vega, MD, PhD

Intravascular large B-cell lymphoma (IVLBCL) involving skin is shown. Note that the infiltration by neoplastic cells is difficult to recognize at this low magnification.

IVLBCL involving the skin is shown. At high power, atypical lymphoid cells are seen inside of small dermal vessels image.



  • Intravascular large B-cell lymphoma (IVLBCL)


  • Angiotropic large cell lymphoma

  • Angioendotheliotropic (intravascular) lymphoma

  • Intravascular lymphomatosis


  • Large B-cell lymphoma characterized by selective intravascular growth

  • Preferential intravascular growth is a condition sine qua non for diagnosing IVLBCL

    • Concomitant and minimal extravascular location of neoplastic cells, usually surrounding involved vessels, can be seen



  • Selective tumor growth within lumina of small blood vessels, particularly capillaries

  • Widely disseminated

  • Any organ can be involved

  • Absence of marked lymphadenopathy

  • Mechanisms responsible for selective growth of neoplastic cells within blood vessel lumina are unknown; possible explanations include

    • Chemokine-chemokine receptor interactions

      • e.g., CXCL9 (expressed in endothelium) and CXCR3 (expressed in IVLBCL)

    • Decreased expression of adhesion molecules on surface of IVLBCL cells

      • e.g., CD29 and CD54


Jul 8, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Intravascular Large B-cell Lymphoma
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