Richter Syndrome Sergej Konoplev, MD, PhD Key Facts Terminology Aggressive lymphoma arising in patient with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) Subtypes Common: Diffuse large B-cell lymphoma Uncommon: Classical Hodgkin…
ALK− Anaplastic Large Cell Lymphoma Francisco Vega, MD, PhD Key Facts Terminology Lymphoma histologically resembling spectrum of ALK(+) ALCL, with strong and uniform expression of CD30, but lacking ALK expression…
Mixed Cellularity Hodgkin Lymphoma C. Cameron Yin, MD, PhD Key Facts Terminology Subtype of classical Hodgkin lymphoma (CHL) with diffuse or interfollicular pattern, without nodular fibrosis Etiology/Pathogenesis Epstein-Barr virus (EBV)…
Plasmablastic Lymphoma Arising in HHV8+ Multicentric Castleman Disease L Jeffrey Medeiros, MD Key Facts Terminology PBL-MCD is a monoclonal proliferation of HHV8(+) plasmablasts that express IgMλ and arise in MCD…
Protocol for Examination of Non-Hodgkin Lymphoma Specimens L. Jeffrey Medeiros, MD Non-Hodgkin Lymphoma/Lymphoid Neoplasms: Biopsy, Resection Surgical Pathology Cancer Case Summary (Checklist) Specimen (select all that apply) ____ Lymph node(s)…
ALK+ Diffuse Large B-cell Lymphoma Tariq Muzzafar, MBBS Key Facts Etiology/Pathogenesis ALK gene abnormalities at chromosome 2p23 appear to be key transforming event Result in formation of fusion genes and…
Diffuse Large B-cell Lymphoma, NOS, Centroblastic Francisco Vega, MD, PhD Key Facts Terminology Diffuse proliferation of large neoplastic B cells composed predominantly of centroblasts Typical: Medium to large cells (10-14…
T-cell/Histiocyte-rich Large B-cell Lymphoma Francisco Vega, MD, PhD Key Facts Terminology Large B-cell lymphoma characterized by scattered large lymphoma cells representing < 10% of total cell population Clinical Issues Young…
Diffuse Large B-cell Lymphoma Associated with Chronic Inflammation Wei Liu, MD, PhD L. Jeffrey Medeiros, MD Key Facts Terminology DLBCL-CI is large B-cell neoplasm that occurs in context of longstanding…
Lymphocyte-depleted Hodgkin Lymphoma C. Cameron Yin, MD, PhD Key Facts Clinical Issues < 1% of cases of CHL Lymph nodes: Retroperitoneal or abdominal > peripheral Abdominal organs, bone marrow B…
