Diffuse Large B-cell Lymphoma, NOS, Centroblastic

Diffuse Large B-cell Lymphoma, NOS, Centroblastic

Francisco Vega, MD, PhD

Diffuse large B-cell lymphoma (DLBCL). Typical centroblasts image are large, noncleaved with vesicular chromatin and have membrane-bound nucleoli. Reactive small lymphocytes are also present image.

DLBCL composed of multilobated centroblasts image. The tumor cells are large, and some have deeply lobated nuclei.



  • Diffuse large B-cell lymphoma (DLBCL), centroblastic


  • Centroblastic lymphoma


  • Diffuse proliferation of large neoplastic B cells composed predominantly of centroblasts

    • Centroblasts

      • Typical: Medium to large cells (10-14 µm) with fine chromatin, 2-3 small nucleoli often closely apposed to nuclear membrane, and scant basophilic cytoplasm

      • Multilobated: Medium to large cells with lobated nuclei (> 3 lobes)



  • Incidence

    • Predominantly disease of adults and elderly but also occurs in children and young adults

    • Most frequent morphologic variant of DLBCL


  • Enlarging mass in nodal or extranodal sites

  • Gastrointestinal tract is frequent extranodal site

  • Stage IV in at least 1/3 of cases

  • Bone marrow involvement occurs less frequently than in patients with low-grade B-cell lymphomas

  • Certain morphologic variants more prevalent at particular extranodal sites

    • Cells with multilobated nuclei in cases involving bone

Jul 8, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Diffuse Large B-cell Lymphoma, NOS, Centroblastic

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