T-cell/Histiocyte-rich Large B-cell Lymphoma



T-cell/Histiocyte-rich Large B-cell Lymphoma


Francisco Vega, MD, PhD










THRLBCL. Scattered, large, atypical cells image are surrounded by numerous small lymphocytes and occasional histiocytes image.






THRLBCL. Large neoplastic cells show membranous reactivity for CD20. Histiocytes image are negative for CD20.


TERMINOLOGY


Abbreviations



  • T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL)


Synonyms



  • T-cell-rich B-cell lymphoma


  • Large B-cell lymphoma rich in T-cells and simulating Hodgkin disease


  • Histiocyte-rich T-cell-rich B-cell lymphoma


  • Histiocyte-rich B-cell lymphoma


Definitions



  • Large B-cell lymphoma characterized by scattered large cells representing < 10% of total cell population


CLINICAL ISSUES


Presentation



  • Young to middle-aged males


  • Advanced clinical stage at diagnosis



    • Commonly involves liver, spleen, and bone marrow


Treatment



  • Rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) is standard


Prognosis



  • Clinically aggressive and often refractory to chemotherapy


MICROSCOPIC PATHOLOGY


Histologic Features

Jul 8, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on T-cell/Histiocyte-rich Large B-cell Lymphoma
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