Thrombotic Microangiopathy, Drugs Neeraja Kambham, MD Key Facts Etiology/Pathogenesis Direct endothelial injury or immune mediated > 60 drugs reportedly associated with TMA, but often difficult to establish causative role Chemotherapeutic…
Giant Cell Arteritis Surya V. Seshan, MD Key Facts Terminology Granulomatous arteritis of aorta and its major branches Etiology/Pathogenesis Possible triggers include exposure to several upper respiratory disease pathogens Associated…
Granulomatosis with Polyangiitis (Wegener) Surya V. Seshan, MD Key Facts Etiology/Pathogenesis Form of ANCA-mediated small vessel vasculitis Usually due to anti-PR3 antibodies (˜ 75%), others to MPO Clinical Issues Peak…
Churg-Strauss Syndrome Surya V. Seshan, MD Key Facts Terminology Synonyms: Allergic granulomatosis and angiitis Etiology/Pathogenesis Triggers: Allergens, vaccines, drugs T-helper cell and eosinophil activation Clinical Issues Occurs in any age,…
Overview and Classification of Systemic Vasculitides Surya V. Seshan, MD This schematic shows the predominant range of vascular involvement by different vasculitides, as described in the Chapel Hill Consensus Conference…
Diffuse Mesangial Sclerosis Helen Liapis, MD Joseph Gaut, MD, PhD Key Facts Terminology Diffuse mesangial sclerosis Etiology/Pathogenesis WT1 mutations (Denys-Drash or Frasier syndromes) Laminin β2 mutations (Pierson syndrome) Idiopathic Clinical…
Monoclonal Immunoglobulin Deposition Disease Lynn D. Cornell, MD Key Facts Clinical Issues Nephrotic syndrome Acute or chronic renal failure Multiple myeloma diagnosable in ˜ 40% of patients with pure MIDD…
Alport Syndrome Helen Liapis, MD Joseph Gaut, MD, PhD Key Facts Etiology/Pathogenesis 85% X-linked inheritance of mutations in COL4A5 15% autosomal recessive COL4A3, COL4A4 Clinical Issues Presentation Hematuria, proteinuria, sensorineural…
Systemic Lupus Erythematosus Shane M. Meehan, MBBCH Key Facts Terminology Systemic autoimmune disease manifested by inflammation of skin, joints, kidneys and central nervous system IgG autoantibodies to DNA, RNA, proteins,…
Idiopathic Nodular Glomerulopathy A. Brad Farris, III, MD Key Facts Terminology Idiopathic nodular glomerulopathy (ING)/glomerulosclerosis (GS) Nodular GS, associated with smoking &/or HTN without DM Etiology/Pathogenesis Smoking leads to physiologic…
