Giant Cell Arteritis

Jul 7, 2016 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Giant Cell Arteritis

Giant Cell Arteritis Surya V. Seshan, MD Key Facts Terminology Granulomatous arteritis of aorta and its major branches Etiology/Pathogenesis Possible triggers include exposure to several upper respiratory disease pathogens Associated…

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Churg-Strauss Syndrome

Jul 7, 2016 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Churg-Strauss Syndrome

Churg-Strauss Syndrome Surya V. Seshan, MD Key Facts Terminology Synonyms: Allergic granulomatosis and angiitis Etiology/Pathogenesis Triggers: Allergens, vaccines, drugs T-helper cell and eosinophil activation Clinical Issues Occurs in any age,…

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Diffuse Mesangial Sclerosis

Jul 7, 2016 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Diffuse Mesangial Sclerosis

Diffuse Mesangial Sclerosis Helen Liapis, MD Joseph Gaut, MD, PhD Key Facts Terminology Diffuse mesangial sclerosis Etiology/Pathogenesis WT1 mutations (Denys-Drash or Frasier syndromes) Laminin β2 mutations (Pierson syndrome) Idiopathic Clinical…

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Alport Syndrome

Jul 7, 2016 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Alport Syndrome

Alport Syndrome Helen Liapis, MD Joseph Gaut, MD, PhD Key Facts Etiology/Pathogenesis 85% X-linked inheritance of mutations in COL4A5 15% autosomal recessive COL4A3, COL4A4 Clinical Issues Presentation Hematuria, proteinuria, sensorineural…

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Idiopathic Nodular Glomerulopathy

Jul 7, 2016 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Idiopathic Nodular Glomerulopathy

Idiopathic Nodular Glomerulopathy A. Brad Farris, III, MD Key Facts Terminology Idiopathic nodular glomerulopathy (ING)/glomerulosclerosis (GS) Nodular GS, associated with smoking &/or HTN without DM Etiology/Pathogenesis Smoking leads to physiologic…

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