Commonly implicated drugs: Anabolic steroids, oral contraceptives, prochlorperazine, thiabendazole, warfarin • Cholestatic hepatitis: Cholestasis with inflammation and hepatocellular damage Macrolide antibiotics (erythromycin), antipsychotics (chlorpromazine), numerous other drugs • Prolonged cholestasis/ductopenia: Cholestasis >…
Portal Tract Showing Paucity of Bile DuctsPortal tract in a case of chronic ductopenic rejection contains a hepatic artery and portal vein but no interlobular bile duct. Intimal Foam Cell…
Amyloid deposits are congophilic and show “apple green” birefringence under polarized light Birefringence is best demonstrated by turning light to maximum and pulling color filters out • Immunohistochemistry P glycoprotein: Present…
Grade 3 tumors: Poorly differentiated neuroendocrine carcinoma (small or large cell type) Tumor in Ampullary RegionLow-power view shows a well-differentiated neuroendocrine neoplasm infiltrating the ampullary region. The overlying mucosa is…
Usually in context of inflammatory process Reportedly 2nd most common type of gallbladder polyp • Metaplastic polyp, mucosal hyperplasia, inflammatory polyp, localized papillary hyperplasia • Historically, a.k.a. metaplastic polyp, mucosal hyperplasia, inflammatory…
Ductal plate malformation Biliary microhamartoma Etiology/Pathogenesis • Developmental malformation resulting from aberrant construction/remodeling of embryonic bile ducts Majority are sporadic Also associated with several fibropolycystic liver diseases Clinical Issues • Reportedly occurs…
Eventually destroys hepatic parenchyma Solid, epithelioid, and spindled areas may be present • Immunopositive for vascular markers: CD31, CD34, factor VIII • Nuclear staining for transcription factors FLI-1 and ERG helps in…
Depending on severity of portal hypertension, biliary infection, and renal disease Microscopic • Marked portal expansion by fibrous tissue Portal-to-portal bridging fibrosis with broad septa • Increased number of irregularly shaped, ectatic,…
Liver Pancreas Heart Thyroid Minor salivary glands • Abnormal iron studies • Liver and multiorgan failure Macroscopic • Shrunken liver • Cirrhosis Microscopic • Marked lobular necrosis with collapse • Regenerative nodules • Pseudoacinar formation • Intracanalicular bile…
