Fig. 28.1 Symmetric, erythematous morbilliform drug reaction in a patient with DRESS syndrome Drug is high risk, such as an aromatic AED Fever Liver abnormalities or other organ involvement Leukocyte…
Most potent phenol and catechol derivatives Non-phenolic/catecholic agents Hydroquinone Mercury Monobenzyl ether of hydroquinone Arsenic p-tert-Butylchatechol Cinnamic aldehyde p-tert-Butylphenol p-phenylenediamine (PPD) p-tert-Amylphenol Benzyl alcohol – Azelaic acid – Corticosteroids –…
Fig. 5.1 A typical morbilliform drug eruption, with pink erythematous papules coalescing into larger plaques Fig. 5.2 Morbilliform drug eruption in an adult patient with pink erythematous papules coalescing into…
Drug-induced alopecia Idiopathic alopecia Temporal association of drug initiation and alopecia No association with initiation of drug Cessation of drug leads to recovery and restoration of hairs and reversion of…
Fig. 19.1 This is true cutaneous lymphoma—erythematous papules in the groin. Clinical clues it is a true lymphoma are that the lesions are multiple, chronic, and on non-sun-exposed skin. The…
Fig. 36.1 Methotrexate nodulosis in a patient with severe long-standing rheumatoid arthritis on methotrexate for years. The nodules are seen over the proximal interphalangeal joints. They are smaller than the…
Antibiotics Antiarrythmics-antihypertensives Vaccines Actinomycin Amoxicillin Ampicillin Cephalexin Ciprofloxacin Chloroquine Dactinomycin Levofloxacin Penicillin Rifampin Ca± channel blockers Amlodipine Nifedipine ACE inhibitors Captopril Enalapril Lisinopril β-blockers Nadolol Practolol Angiotensin II antagonists Losartan…
Fig. 4.1 Exanthematous (morbilliform) drug eruption. Erythematous macules and papules, some coalescing After withdrawal of the offending medication, the rash resolves in 1–2 weeks without sequelae. Treatment is not required,…
Allopurinol Beta-blockers Androgens Ergots Anticholesterol agents (statins) Hormones (OCPs, HRT) Anticoagulants Dopa Anticonvulsants Immunomodulators Antifungals Retinoids (vitamin A) Antihistamines (H2) Psychotropics Anti-inflammatory Minoxidil Anti-mitotic Heavy metals (gold) Anti-thyroid SERMS and…
Drug-induced psoriasisiform eruption Idiopathic psoriasis Temporal association of drug initiation and onset of eruption No association with initiation of drug(s) Cessation of drug prevents disease progression No recovery after cessation…
