Chemotherapy and Cutaneous Drug Reactions

Nov 20, 2016 by in PHARMACY Comments Off on Chemotherapy and Cutaneous Drug Reactions

Fig. 29.1 Xerosis: significant dryness of the skin of the foot Fig. 29.2 Xerosis: fissures of the hands Dry skin can be attributed to abnormal keratinocyte differentiation, which leads to…

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Fixed Drug Eruptions

Nov 20, 2016 by in PHARMACY Comments Off on Fixed Drug Eruptions

Fig. 17.1 Adult with multiple FDE due to a Cephalosporin Fig. 17.2 Recurrent localized FDE. Hyperpigmented patch with surrounding violaceous erythema Fig. 17.3 Bulla formation in localized FDE The first…

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Neutrophilic Dermatoses

Nov 20, 2016 by in PHARMACY Comments Off on Neutrophilic Dermatoses

Condition Appearance Location Histopathology Associations Sweet’s syndrome Papules, plaques, nodules Head, neck, upper extremity Massive papillary dermal edema, nodular and diffuse neutrophilic infiltration with karyorrhexis Fever, leukocytosis, arthralgias Pyoderma gangrenosum…

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Cutaneous Drug Reactions to Anticoagulants

Nov 20, 2016 by in PHARMACY Comments Off on Cutaneous Drug Reactions to Anticoagulants

  Warfarin-induced skin necrosis Heparin-induced skin necrosis Heparin delayed-type hypersensitivity Incidence 0.01–0.1 % UFH: <3 % LMWH: <0.1 % 7.5 % Onset 90 % day 3–6 Almost all by day…

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Histopathology of Drug Reactions

Nov 20, 2016 by in PHARMACY Comments Off on Histopathology of Drug Reactions

and Beth Ruben2 (1) Pathology, Miraca Life Sciences, Irving, TX, USA (2) Dermatology and Pathology, University of California, San Francisco, CA, USA   Abstract Cutaneous drug reactions can produce a variety…

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Cutaneous Reactions to BRAF Inhibitors

Nov 20, 2016 by in PHARMACY Comments Off on Cutaneous Reactions to BRAF Inhibitors

Fig. 32.1 Clinical presentation of the maculopapular rash after 2 weeks of therapy with vemurafenib (Courtesy of Rinderknecht et al. (2013)) Fig. 32.2 Histology of the maculopapular rash demonstrates a…

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Cutaneous Reactions to Corticosteroids

Nov 20, 2016 by in PHARMACY Comments Off on Cutaneous Reactions to Corticosteroids

Fig. 33.1 Severe tinea corporis of the leg due to trichophytun rubrum. It started out much less prominent, but topical and systemic corticosteroid use caused the leg to swell and…

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