CHAPTER 36 Natural anticoagulants and thrombophilia E. Norström, G. Escolar Chapter contents INTRODUCTION 583 COAGULATION 584 Classic cascade mechanism of coagulation vs. cell-based models of thrombin generation 584 Molecular mechanism…
CHAPTER 21 Molecular studies in myeloproliferative and myelodysplastic/myeloproliferative neoplasms O. Bock, HH. Kreipe Chapter contents INTRODUCTION 321 THE PHILADELPHIA CHROMOSOME AND BCR-ABL IN CHRONIC MYELOGENOUS LEUKEMIA 322 THE JANUS KINASE…
CHAPTER 13 Aplastic anemia and pure red cell aplasia EC. Gordon-Smith Chapter contents ACQUIRED APLASTIC ANEMIA 213 Definition and differential diagnosis 213 Etiology 214 Drugs 214 Industrial/domestic chemicals 214 Viruses…
CHAPTER 35 Acquired bleeding disorders DJ. Perry, C. Grove Chapter contents INTRODUCTION 566 PHYSIOLOGICAL DEFICIENCIES 566 Neonates 566 DRUG-INDUCED BLEEDING DISORDERS 566 Heparin 566 Laboratory monitoring 566 Hirudin and bivalirudin…
CHAPTER 38 Transfusion medicine for pathologists J. McCullough Chapter contents INTRODUCTION 620 BLOOD SUPPLY SYSTEMS THROUGHOUT THE WORLD 620 Whole blood 620 Blood donor recruitment 620 Plasma 621 WHOLE BLOOD…
CHAPTER 6 Investigation and classification of anemia WN. Erber Chapter contents DEFINITION AND CAUSES OF ANEMIA 105 CLINICAL FEATURES OF ANEMIA 105 THE BLOOD COUNT AND RED CELL INDICES IN…
CHAPTER 17 Disorders of phagocyte function G. Bouma, AJ. Thrasher Chapter Contents INTRODUCTION 263 DISORDERS OF PHAGOCYTE MATURATION 263 DEFICIENCIES OF ADHESION AND MIGRATION 266 PHAGOCYTE SIGNALING ABNORMALITIES 267 DEFICIENCIES…
CHAPTER 7 Abnormalities of the red cell membrane J. Delaunay Chapter contents HEREDITARY SPHEROCYTOSIS 115 ANK1 gene mutations 116 SLC4A1 gene mutations 116 SPTB gene mutations 118 EPB42 gene mutations…
CHAPTER 4 Regulation of hematopoiesis SM. Buckley, C. Verfaillie Chapter contents INTRODUCTION 63 CHARACTERISTICS OF HEMATOPOIETIC STEM AND PROGENITOR CELLS 63 Phenotypic characterization 64 Functional characterization 64 HEMATOPOIETIC STEM CELL…
