Basicmedical Key

Fusion-Driven Round Cell Sarcomas

May 10, 2026 by drzezo in PATHOLOGY & LABORATORY MEDICINE Comments Off on Fusion-Driven Round Cell Sarcomas

The neoplasms described in this chapter are a heterogeneous group of tumors, with uncertain histogenesis and no known normal tissue counterpart. Each is characterized by its own distinctive clinical and…

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Emerging Entities

May 10, 2026 by drzezo in PATHOLOGY & LABORATORY MEDICINE Comments Off on Emerging Entities

GLI1 -Altered Neoplasms GLI1 -altered malignant neoplasms are an emerging group of tumors characterized by predominantly epithelioid morphology and GLI1 gene alterations, including gene fusions and amplifications. Tumors harboring GLI1…

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Benign Lipomatous Tumors

May 10, 2026 by drzezo in PATHOLOGY & LABORATORY MEDICINE Comments Off on Benign Lipomatous Tumors

The significance and multiple functions of fat are not always fully appreciated. Fat serves not only as one of the principal and most readily available sources of energy in the…

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Liposarcoma

May 10, 2026 by drzezo in PATHOLOGY & LABORATORY MEDICINE Comments Off on Liposarcoma

Liposarcoma, accounting for 15% to 25% of all sarcomas, is the most common sarcoma of adults. There are several subtypes, which are histologically, biologically, and genetically distinct from one another…

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Myxoid Soft Tissue Tumors: Benign, Borderline and Malignant

May 10, 2026 by drzezo in PATHOLOGY & LABORATORY MEDICINE Comments Off on Myxoid Soft Tissue Tumors: Benign, Borderline and Malignant

This chapter discusses a heterogeneous group of myxoid soft tissue tumors, spanning a clinicopathological spectrum from benign tumors (or pseudotumors), to tumors of borderline malignancy, and low-grade myxoid sarcomas. It…

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Benign Vascular Tumors and Malformations

May 10, 2026 by drzezo in PATHOLOGY & LABORATORY MEDICINE Comments Off on Benign Vascular Tumors and Malformations

The term hemangioma has been used broadly in the past to describe any benign, nonreactive vascular process with an increase in normal or abnormal-appearing vessels or simply abnormally configured vessels….

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Osteocartilaginous Soft Tissue Tumors, Tumoral Calcinosis and Amyloidoma

May 10, 2026 by drzezo in PATHOLOGY & LABORATORY MEDICINE Comments Off on Osteocartilaginous Soft Tissue Tumors, Tumoral Calcinosis and Amyloidoma

Benign extraosseous cartilaginous lesions are uncommon and usually present as tumor-like masses. In the past, the term soft part chondroma or extraskeletal chondroma was used arbitrarily for small, well-defined, solitary…

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Tumors and Tumor-Like Lesions of Synovial Tissue

May 10, 2026 by drzezo in PATHOLOGY & LABORATORY MEDICINE Comments Off on Tumors and Tumor-Like Lesions of Synovial Tissue

The synovial membrane forms the lining of joints, tendons, and bursae. In addition, its cells synthesize hyaluronate, a major component of synovial fluid, and facilitate the exchange of substances between…

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Rhabdomyosarcoma

May 10, 2026 by drzezo in PATHOLOGY & LABORATORY MEDICINE Comments Off on Rhabdomyosarcoma

Introduction Although “rhabdomyosarcoma” was once regarded as a single disease, it has become abundantly clear over the past several decades that they are in fact a family of genetically distinct…

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Angiosarcoma, Atypical Vascular Lesions Following Irradiation, and Kaposi Sarcoma

May 10, 2026 by drzezo in PATHOLOGY & LABORATORY MEDICINE Comments Off on Angiosarcoma, Atypical Vascular Lesions Following Irradiation, and Kaposi Sarcoma

Angiosarcoma Angiosarcomas are malignant tumors that recapitulate many of the functional and morphologic features of normal endothelium. They vary from highly differentiated tumors resembling a hemangioma to anaplastic lesions difficult…

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