Acne and Drug Reactions
Fig. 15.1 Primary lesions Secondary Lesions Comedones and cysts can arise secondary to inflammatory papules and pustules but are often not present. Pits and scars are evident in severe cases….
PHARMACY
Antiepileptic Medications and Cutaneous Drug Reactions
Fig. 28.1 Symmetric, erythematous morbilliform drug reaction in a patient with DRESS syndrome Drug is high risk, such as an aromatic AED Fever Liver abnormalities or other organ involvement Leukocyte…
Drug Eruptions and Erythroderma
Diseases commonly associated with or preceding erythroderma a Dermatologic diseases Psoriasis Atopic dermatitis Pityriasis rubra pilaris Contact and other types of dermatitis Dermatophytosis Ichthyosis Pemphigus foliaceus Systemic diseases Lymphoma: CTCL,…
Pigment Changes and Drug Reactions
Most potent phenol and catechol derivatives Non-phenolic/catecholic agents Hydroquinone Mercury Monobenzyl ether of hydroquinone Arsenic p-tert-Butylchatechol Cinnamic aldehyde p-tert-Butylphenol p-phenylenediamine (PPD) p-tert-Amylphenol Benzyl alcohol – Azelaic acid – Corticosteroids –…
Morbilliform Drug Eruptions
Fig. 5.1 A typical morbilliform drug eruption, with pink erythematous papules coalescing into larger plaques Fig. 5.2 Morbilliform drug eruption in an adult patient with pink erythematous papules coalescing into…
Drug-Induced Alopecia
Drug-induced alopecia Idiopathic alopecia Temporal association of drug initiation and alopecia No association with initiation of drug Cessation of drug leads to recovery and restoration of hairs and reversion of…
Lymphoma and Pseudolymphoma and Drug Reactions
Fig. 19.1 This is true cutaneous lymphoma—erythematous papules in the groin. Clinical clues it is a true lymphoma are that the lesions are multiple, chronic, and on non-sun-exposed skin. The…
Granulomatous Drug Reactions
Fig. 36.1 Methotrexate nodulosis in a patient with severe long-standing rheumatoid arthritis on methotrexate for years. The nodules are seen over the proximal interphalangeal joints. They are smaller than the…
Autoimmune Bullous Diseases and Drugs
Antibiotics Antiarrythmics-antihypertensives Vaccines Actinomycin Amoxicillin Ampicillin Cephalexin Ciprofloxacin Chloroquine Dactinomycin Levofloxacin Penicillin Rifampin Ca± channel blockers Amlodipine Nifedipine ACE inhibitors Captopril Enalapril Lisinopril β-blockers Nadolol Practolol Angiotensin II antagonists Losartan…
Principles of Treatment of Cutaneous Drug Eruptions
Fig. 4.1 Exanthematous (morbilliform) drug eruption. Erythematous macules and papules, some coalescing After withdrawal of the offending medication, the rash resolves in 1–2 weeks without sequelae. Treatment is not required,…
