Basaloid Carcinoma Antonio L. Cubilla, MD Alcides Chaux, MD Elsa F. Velazquez, MD Key Facts Etiology/Pathogenesis HPV is detected in most cases Serotype 16 is most common Clinical Issues Represents…

Papillary Carcinoma Antonio L. Cubilla, MD Alcides Chaux, MD Elsa F. Velazquez, MD Key Facts Terminology Represents 5-15% of all penile SCC Accounts for 27-53% of all verruciform tumors Etiology/Pathogenesis…

Verrucous Carcinoma Elsa F. Velazquez, MD Antonio L. Cubilla, MD Key Facts Clinical Issues Unicentric tumors are more frequent Multicentric tumors may occur Some cases may be associated with longstanding…

Carcinoma Cuniculatum Antonio L. Cubilla, MD Alcides Chaux, MD Elsa F. Velazquez, MD Key Facts Macroscopic Features Large exoendophytic tumor with “cobblestone” appearance Affects several anatomical compartments (glans, coronal sulcus,…

Metastatic Tumors, Penis Antonio L. Cubilla, MD Alcides Chaux, MD Elsa F. Velazquez, MD Key Facts Terminology GU tumors are most common primary sites Bladder urothelial carcinomas and prostatic adenocarcinomas…

Sarcomatoid Carcinoma, Penis Elsa F. Velazquez, MD Antonio L. Cubilla, MD Key Facts Terminology Synonyms Spindle cell carcinoma, carcinosarcoma Macroscopic Features Large polypoid mass usually affecting glans, coronal sulcus, and…

Warty Carcinoma Elsa F. Velazquez, MD Antonio L. Cubilla, MD Key Facts Terminology Condylomatous carcinoma Etiology/Pathogenesis HPV-related tumor Clinical Issues Papillomatous tumor with cobblestone appearance usually affecting glans Macroscopic Features…

Teratoma Steven S. Shen, MD, PhD Jae Y. Ro, MD, PhD Key Facts Terminology Tumors with somatic tissue of different germinal layers (ectoderm, mesoderm, or endoderm) Clinical Issues 2nd most…

Penile Intraepithelial Neoplasia (PeIN) Elsa F. Velazquez, MD Antonio L. Cubilla, MD Key Facts Terminology Most warty/basaloid PeIN replace most or entire thickness of epithelium and represent carcinoma in situ…

Paget Disease Elsa F. Velazquez, MD Antonio L. Cubilla, MD Key Facts Terminology Extramammary Paget disease (EMPD) Clinical Issues Erythematous patches or plaques with sharply defined borders May clinically mimic…