Warty Carcinoma



Warty Carcinoma


Elsa F. Velazquez, MD

Antonio L. Cubilla, MD










Cut section of a partial penectomy specimen shows a cauliflower, complex, papillomatous neoplasm deeply invading into corpus spongiosum, a warty (condylomatous) carcinoma.






Diagram shows a warty carcinoma infiltrating the corpus spongiosum. Carcinoma image, corpus spongiosum image, corpus cavernosum image, and urethra image are shown.


TERMINOLOGY


Abbreviations



  • Warty carcinoma (WC)


Synonyms



  • Condylomatous carcinoma


Definitions



  • Tumor related to human papilloma virus (HPV)



    • Shares some gross and microscopic characteristics with condyloma


    • Definitive malignant histology and metastatic potential


ETIOLOGY/PATHOGENESIS


Etiology



  • HPV-related in majority of cases (most cases associated with HPV-16)


Pathogenesis



  • HPV oncoproteins E6 and E7 appear crucial in process of carcinogenesis


  • E6 interferes with p53 pathway, causing suppression of p53 normal inhibitory function of cell cycle


  • E7 targets retinoblastoma protein (pRB) interfering with p16/cyclin-D1/rb pathway

Jul 7, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Warty Carcinoma

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