Angiomyolipoma Joseph Misdraji, MD Key Facts Terminology Rare benign mesenchymal neoplasm composed of smooth muscle, adipose tissue, and vessels Clinical Issues Infrequently associated with tuberous sclerosis (6-10%) Benign behavior in…
Angiosarcoma Laura Webb Lamps, MD Key Facts Terminology Most common primary hepatic sarcoma Etiology/Pathogenesis 25-40% of cases associated with vinyl chloride, Thorotrast, arsenic, or steroids Clinical Issues Predominantly older patients,…
Infantile Hemangioendothelioma Grace E. Kim, MD Key Facts Clinical Issues Most common hepatic neoplasm in 1st year of life > 90% present before age of 6 months Microscopic Pathology Vascular…
Intrahepatic Cholangiocarcinoma Matthew M. Yeh, MD, PhD Key Facts Clinical Issues Incidence has been increasing around world, including USA Very prevalent in Asia, particularly in northeastern Thailand Well-known risk factors…
Biliary Cystadenoma and Cystadenocarcinoma Matthew M. Yeh, MD, PhD Key Facts Clinical Issues Biliary cystadenoma almost exclusively occurs in women CA19-9 and CEA in cyst fluid helps differentiate between simple…
Regenerative and Dysplastic Nodules Sanjay Kakar, MD Key Facts Clinical Issues RN: Regenerative nodule greater than 1 cm; most believed to be nonneoplastic LGDN resemble RN morphologically but are clonal…
Hepatocellular Carcinoma and Variants Joseph Misdraji, MD Laura Webb Lamps, MD Key Facts Etiology/Pathogenesis Chronic viral hepatitis is leading cause of HCC worldwide 70-90% of HCC arises in cirrhosis Clinical…
von Meyenburg Complex (Biliary Microhamartoma) Sanjay Kakar, MD Key Facts Terminology Developmental malformation resulting from aberrant construction/remodeling of embryonic bile ducts Etiology/Pathogenesis Most often sporadic; also associated with several fibropolycystic…
Peribiliary Hamartoma (Bile Duct Adenoma) Sanjay Kakar, MD Key Facts Terminology Historically called “bile duct adenoma” but shown to have phenotype of peribiliary glands rather than bile ducts Clinical Issues…
Focal Nodular Hyperplasia Matthew M. Yeh, MD, PhD Key Facts Terminology Benign tumor-like lesion of liver caused by hyperplastic response to localized vascular abnormality Clinical Issues Mostly incidental finding on…
