von Meyenburg Complex (Biliary Microhamartoma)

von Meyenburg Complex (Biliary Microhamartoma)

Sanjay Kakar, MD

This small, subcapsular VMC features branching, irregular, angulated glands embedded in a dense fibrous stroma.

The branching, angulated glands in VMC are lined by a single layer of flattened cuboidal epithelium. There is no nuclear atypia.



  • von Meyenburg complex (VMC)


  • Biliary microhamartoma

  • Ductal plate malformation


  • Developmental malformation resulting from aberrant construction/remodeling of embryonic bile ducts


Developmental Anomaly

  • Within spectrum of fibropolycystic diseases of liver

    • Most often sporadic

    • Also associated with numerous fibropolycystic diseases including congenital hepatic fibrosis, Caroli disease, autosomal dominant polycystic disease

      • Considered precursor lesion of autosomal dominant polycystic liver disease

      • Basic lesion of congenital hepatic fibrosis

Jul 7, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on von Meyenburg Complex (Biliary Microhamartoma)

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