Nevus Lipomatosus Steven D. Billings, MD Key Facts Terminology Connective tissue nevus characterized by mature adipose tissue in reticular dermis Clinical Issues Solitary or multiple grouped papules or polypoid lesions…

Spindle Cell and Pleomorphic Lipoma Amitabh Srivastava, MD Key Facts Terminology Benign adipocytic tumors with variable admixture of spindle cells, mucinous stroma, ropey collagen, and multinucleate giant cells Clinical Issues…

Chondroid Lipoma Khin Thway, BSc, MBBS, FRCPath Key Facts Terminology Uncommon benign neoplasm with features of embryonal fat and embryonal cartilage Balanced translocation t(11;16)(q13; p12-13) in some cases; thought to…

Angiolipoma Amitabh Sricatava, MD Key Facts Terminology Biphasic tumor consisting of mature adipocytes and thin-walled blood vessels with fibrinoid thrombi Clinical Issues Common in young adults; male predominance Painful tender…

Lipoma Amitabh Srivastava, MD Key Facts Terminology Benign tumor of mature white adipocytes Clinical Issues Surgical excision is curative Higher recurrence rate in intramuscular lipoma Macroscopic Features Most common between…

Cutaneous Rhabdomyosarcoma Khin Thway, BSc, MBBS, FRCPath Key Facts Terminology Malignant soft tissue tumor that shows variable differentiation toward skeletal muscle 3 main subtypes Alveolar rhabdomyosarcoma (ARMS) Embryonal rhabdomyosarcoma (ERMS)…

Leiomyosarcoma Elizabeth A. Montgomery, MD Key Facts Terminology Malignant neoplasm composed of cells exhibiting smooth muscle differentiation Etiology/Pathogenesis Epstein-Barr virus associated in immunosuppressed patients Clinical Issues Superficial or deep soft…

Rhabdomyoma Cyril Fisher, MD, DSc, FRCPath Key Facts Terminology Benign tumor with skeletal muscle differentiation Extracardiac tumors can be of adult or fetal histologic type Etiology/Pathogenesis Some fetal rhabdomyomas associated…

Leiomyoma (Pilar) Cyril Fisher, MD, DSc, FRCPath Key Facts Terminology Benign cutaneous smooth muscle neoplasm arising from arrector pili muscles Etiology/Pathogenesis Many are shown to have germline fumarate hydratase gene…

Angioleiomyoma Cyril Fisher, MD, DSc, FRCPath Key Facts Terminology Benign neoplasm composed of blood vessels and smooth muscle cells in varying proportions Clinical Issues Most common between 40-60 years Mostly…