Benign Metastasizing Leiomyoma Elizabeth A. Montgomery, MD Key Facts Terminology Rare lesion usually typified by multiple benignappearing smooth muscle neoplasms of lung in women with coexisting or past uterine leiomyoma…
Mammary-Type Myofibroblastoma Cyril Fisher, MD, DSc, FRCPath Key Facts Terminology Benign spindle cell lesion of modified smooth muscle cells in fibrous and fatty stroma Clinical Issues Identical to mammary myofibroblastoma…
Intravascular Leiomyomatosis Elizabeth A. Montgomery, MD Key Facts Terminology Rare condition featuring growth of nodules of benign smooth muscle in veins of myometrium, some with extension into extrauterine veins Clinical…
Leiomyomatosis Peritonealis Disseminata Cyril Fisher, MD, DSc, FRCPath Key Facts Etiology/Pathogenesis Associated with Pregnancy Hormonal therapy Hormone-secreting tumors Clinical Issues Females Fertile period Especially in 4th decade Throughout abdomen and…
Alveolar Rhabdomyosarcoma Khin Thway, BSc, MBBS, FRCPath Key Facts Terminology High-grade malignant round cell neoplasm showing partial differentiation towards skeletal muscle Etiology/Pathogenesis Characteristic PAX-FOXO1 balanced translocations in most t(2;13)(q35;q14) (majority)…
Sinonasal Hemangiopericytoma Jonathan B. McHugh, MD Key Facts Clinical Issues Accounts for < 0.5% of sinonasal neoplasms Peak incidence in 6th-7th decades Most frequently involve nasal cavity Excellent overall 5-year…
Spindle Cell Rhabdomyosarcoma Khin Thway, BSc, MBBS, FRCPath Key Facts Terminology Uncommon subtype of rhabdomyosarcoma occurring in both children and adults; composed of largely cellular proliferation of predominantly spindled cells…
Embryonal Rhabdomyosarcoma Khin Thway, BSc, MBBS, FRCPath Key Facts Terminology Malignant soft tissue tumor that shows variable differentiation toward skeletal muscle Encompasses botryoid, spindle cell, and anaplastic variants Clinical Issues…
Pleomorphic Rhabdomyosarcoma Khin Thway, BSc, MBBS, FRCPath Key Facts Terminology High-grade sarcoma occurring almost exclusively in adults and displaying evidence of skeletal muscle differentiation Diagnosis requires identification of pleomorphic rhabdomyoblasts…
Congenital Smooth Muscle Hamartoma Steven D. Billings, MD Key Facts Terminology Rare lesion presenting in infants, characterized by disorganized proliferation of benign smooth muscle bundles in dermis, often involving subcutis…
