Intravascular Leiomyomatosis

Intravascular Leiomyomatosis

Elizabeth A. Montgomery, MD

Hematoxylin & eosin from a hysterectomy specimen shows intravascular growth of the lesion, which is more cellular than the investing vessels.

Hematoxylin & eosin shows the intravascular process at high magnification. Note the delicate longitudinal striations of the spindle cells image.



  • Intravenous leiomyomatosis


  • Rare condition featuring growth of nodules of benign smooth muscle in veins of myometrium, some with extension into extrauterine veins



  • Not applicable

  • Usually premenopausal women

    • Median age: Early 40s

  • Abnormal vaginal bleeding

  • Pelvic pain

  • Enlarged uterus

  • Some patients (10-20%) have tumor extending into vena cava or heart

    • Present with cardiac symptoms

Jul 9, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Intravascular Leiomyomatosis
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