Contemporary Gleason Grading System
Fig. 2.1 Comparison of the diagrams of the original Gleason grading system (a) and the ISUP 2005 modified Gleason grading system (b). (a Used with permission from [5]. b Used…
PATHOLOGY & LABORATORY MEDICINE
New Molecular Markers of Diagnosis and Prognosis in Prostate Cancer
Biomarker Functional role Clinical application Category AMACR β-oxidation of branched chain fatty acids Diagnostic Tissue TMPRSS2:ERG gene fusions Oncogenic transcription factor Diagnostic, prognostic, predictive Tissue or urine GSTP1 Caretaker gene…
Clinical and Management Implications Associated with Histologic Subtypes of Renal Cell Carcinomas
Asymptomatic (60 %) Symptomatic (40 %) Tumor related Flank pain Hematuria Abdominal mass Lower extremity edema Metastasis related Bone pain Neurologic symptoms Persistent cough, hemoptysis Paraneoplastic syndromes (5–10 %) Hypercalcemia…
Surgical Pathology Reporting of Renal Cell Carcinomas
Fig. 25.1 Clear cell carcinoma with coagulative tumor necrosis. True coagulative tumor necrosis, in contrast to hyalinized areas of scarring and regression often seen in clear cell RCC, consists of…
New Molecular Markers with Diagnostic and Prognostic Values in Bladder Cancer
Fig. 18.1 In normal urothelium and in reactive atypia CK20 expression is limited to the umbrella cell layer (a); CD44 stains predominantly the basal cell layer, although patchy positivity can…
Independent Predictors of Clinical Outcomes and Prediction Models for Renal Tumor Pathology
Feature Described association Reference Tumor-related characteristics Lymph node involvement (N stage) Survival outcome, RFS Pantuck [74] Distant metastases (M stage) Survival outcome Zisman et al. [18] Fuhrman grade Survival outcome, RFS…
Prostate Cancer Reporting on Biopsy and Radical Prostatectomy Specimens
Gleason grades/score Usual scenario: primary + secondary patterns Special scenarios: see Tables 4.2 and 4.3 Number of positive cores Tumor quantitation/extent (percent involvement and/or linear extent in mm) Treatment-related changes Table…
Genetic and Epigenetic Alterations in Testicular Tumors
© Springer Science+Business Media New York 2015Cristina Magi-Galluzzi and Christopher G. Przybycin (eds.)Genitourinary Pathology10.1007/978-1-4939-2044-0_42 42. Genetic and Epigenetic Alterations in Testicular Tumors Pallavi A. Patil1 and Cristina Magi-Galluzzi1 (1) Department of Pathology, Cleveland Clinic, Robert J. Tomsich…
Familial Syndromes Associated with Testicular Tumors
Familial syndrome Gene localization Candidate gene/locus Gene function Testicular lesion/s Familial germ cell tumors 12q22 5q31 KITLG SPRY4 Inhibitor of the MAPK signaling pathway Inhibitor of the MAPK signaling pathway…
Clinical Implications of the Different Histologic Subtypes of Testicular Tumors
© Springer Science+Business Media New York 2015Cristina Magi-Galluzzi and Christopher G. Przybycin (eds.)Genitourinary Pathology10.1007/978-1-4939-2044-0_38 38. Clinical Implications of the Different Histologic Subtypes of Testicular Tumors Timothy Gilligan1 (1) Taussig Cancer Institute, Cleveland Clinic, Mail Code R359500…
