456 Diseases of the Spinal Cord Stephen L. Hauser, Allan H. Ropper   Diseases of the spinal cord are frequently devastating. They produce quadriplegia, paraplegia, and sensory deficits far beyond…

FIGURE 415e-3   Factors released by the adipocyte that can affect peripheral tissues. IL-6, interleukin 6; PAI, plasminogen activator inhibitor; RBP4, retinal binding protein 4; TNF, tumor necrosis factor. ETIOLOGY OF OBESITY…

289e   Tumors and Trauma of the Heart Eric H. Awtry, Wilson S. Colucci TUMORS OF THE HEART PRIMARY TUMORS Primary tumors of the heart are rare. Approximately three-quarters are histologically…

459 Peripheral Neuropathy Anthony A. Amato, Richard J. Barohn   Peripheral nerves are composed of sensory, motor, and autonomic elements. Diseases can affect the cell body of a neuron or…

84   The Practice of Genetics in Clinical Medicine Susan M. Domchek, J. Larry Jameson, Susan Miesfeldt   APPLICATIONS OF MOLECULAR GENETICS IN CLINICAL MEDICINE Genetic testing for inherited abnormalities associated…

140   Disorders of Platelets and Vessel Wall Barbara A. Konkle   Hemostasis is a dynamic process in which the platelet and the blood vessel wall play key roles. Platelets become…

452 Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases Robert H. Brown, Jr.   AMYOTROPHIC LATERAL SCLEROSIS Amyotrophic lateral sclerosis (ALS) is the most common form of progressive motor neuron…

336   Dialysis in the Treatment of Renal Failure Kathleen D. Liu, Glenn M. Chertow Dialysis may be required for the treatment of either acute or chronic kidney disease. The use of…

339   Polycystic Kidney Disease and Other Inherited Disorders of Tubule Growth and Development Jing Zhou, Martin R. Pollak The polycystic kidney diseases are a group of genetically heterogeneous disorders and…

Part 3: Genes, the Environment, and Disease   82   Principles of Human Genetics J. Larry Jameson, Peter Kopp   IMPACT OF GENETICS AND GENOMICS ON MEDICAL PRACTICE The prevalence of…