Pericardial Disease
MITRAL REGURGITATION ETIOLOGY MR may result from an abnormality or disease process that affects any one or more of the five functional components of the mitral valve apparatus (leaflets, annulus,…
GENERAL & FAMILY MEDICINE
Approach to the Patient with Liver Disease
Atypical presentation and pain patterns are common, especially in the very old or the very young. Diagnosing appendicitis in children can be especially challenging because they tend to respond so…
Microbial Bioterrorism
Part 9: Terrorism and Clinical Medicine 261e Microbial Bioterrorism H. Clifford Lane, Anthony S. Fauci Descriptions of the use of microbial pathogens as potential weapons of war or terrorism date…
Polycythemia Vera and Other Myeloproliferative Neoplasms
UNSTABLE HEMOGLOBINS Amino acid substitutions that reduce solubility or increase susceptibility to oxidation result in unstable hemoglobins that precipitate, forming inclusion bodies injurious to the RBC membrane. Representative mutations are…
Mental Disorders
462e Muscular Dystrophies and Other Muscle Diseases Anthony A. Amato, Robert H. Brown, Jr. Skeletal muscle diseases, or myopathies, are disorders with structural changes or functional impairment of muscle….
Gynecologic Malignancies
114 Bladder and Renal Cell Carcinomas Howard I. Scher, Jonathan E. Rosenberg, Robert J. Motzer BLADDER CANCER Transitional cell epithelium lines the urinary tract from the renal pelvis to…
Hypopituitarism
PART 16: Endocrinology and Metabolism SECTION 1 ENDOCRINOLOGY 399 Approach to the Patient with Endocrine Disorders J. Larry Jameson The management of endocrine disorders requires a broad understanding of…
Concussion and Other Traumatic Brain Injuries
456 Diseases of the Spinal Cord Stephen L. Hauser, Allan H. Ropper Diseases of the spinal cord are frequently devastating. They produce quadriplegia, paraplegia, and sensory deficits far beyond…
Disorders of the Autonomic Nervous System
452 Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases Robert H. Brown, Jr. AMYOTROPHIC LATERAL SCLEROSIS Amyotrophic lateral sclerosis (ALS) is the most common form of progressive motor neuron…
Mitochondrial DNA and Heritable Traits and Diseases
84 The Practice of Genetics in Clinical Medicine Susan M. Domchek, J. Larry Jameson, Susan Miesfeldt APPLICATIONS OF MOLECULAR GENETICS IN CLINICAL MEDICINE Genetic testing for inherited abnormalities associated…
