Hemoglobins
Figure 11-2 The structure of a hemoglobin subunit. Each subunit has eight helical regions, designated A to H. The two most conserved amino acids are shown: His92, the histidine to which the…
Screening in Populations
Figure 18-1 Cumulative incidence (per 10,000) of colon cancer versus age in individuals with and without a family history of the disease. The challenge going forward is to screen populations, independent…
of Developmental Mechanisms in Embryogenesis
Figure 14-23 This scanning electron micrograph of a 4-week human embryo illustrates the early budding of the forelimb. Overlaid onto the bud are the three axes of limb specification: Do-V, dorsal-ventral (dorsal…
Variation and Polymorphism in DNA
bp, Base pair; kb, kilobase pair; Mb, megabase pair. Figure 4-1 Three polymorphisms in genomic DNA from the segment of the human genome reference assembly shown at the top (see also…
Case Studies Illustrating Genetic Principles
Case 1. Abacavir-Induced Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis (Genetically Determined Immunological Adverse Drug Reaction)
Human Genome and the Chromosomal Basis of Heredity
Figure 2-1 The human genome, encoded on both nuclear and mitochondrial chromosomes. See Sources & Acknowledgments. In addition to the nuclear genome, a small but important part of the human genome…
for Specific Topics
References for Specific Topics Biesecker LG. Incidental variants are critical for genomics. Am J Hum Genet. 2013;92:648–651. Elger B, Michaud K, Mangin P. When information can save lives: the duty…
