(1) Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel KeywordsDPNHPyridine nucleotidesNADH fluorescence spectraUV light absorption by NADHState 4–3 transitionIsolated mitochondriaIn vivo NADH spectrum 3.1 Introduction It is now 60…
(1) Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel KeywordsMultiparametric approachMinimally invasive techniquesTissue compartmentsMicrocirculatory blood flowHemoglobin oxygenationTissue pO2 Ionic homeostasisLaser Doppler flowmetry 5.1 Introduction Evaluation of brain physiological functions,…
(1) Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel KeywordsMonitoring of NADH in vivoMonitoring of different organsMonitoring of various animals 8.1 Introduction Since the early stages of NADH monitoring…
(1) Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel KeywordsIn vivo monitoringMetabolic stateIn vivo versus in vitroVitality indexPatient monitoring In this book, I tried to provide the reader with…
(1) Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel KeywordsTissue oxygen balanceEnergy demandEnergy supplyATP consumptionOxygen gradient 2.1 Tissue Energy Metabolism The functional capacity of any tissue is related to…
(1) Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel KeywordsMitochondrial functionNADH fluorescenceIn vivo monitoringOxygen balanceMultiparametric monitoring 1.1 The Mitochondrion The understanding of mitochondrial function has been a challenge for…
Fig. 7.1 The mechanism underlying NO-repressed autophagy. NO inhibits JNK1 phosphorylation by S-nitrosylation. Decrease of phospho-Bcl-2 and increase of Bcl-2-Beclin1 interaction disrupt Vps34-Beclin1 association. NO also inhibits IKKb phosphorylation by S-nitrosylation….
Group A415 A476 Control 24 h 0.044 ± 0.001 0.042 ± 0.004 ART 24 h 0.145 ± 0.002* 0.110 ± 0.003** ART 48 h 0.033 ± 0.001* 0.123 ± 0.002** ART 96 h 0.049 ± 0.002* 0.131 ± 0.002** ART artemisinin. The singular asterisk (*) represents statistically significant difference from…
Metabolites Pathways and genes Up/downregulation folds CR ART H2O2 Glucose Glycolysis Acs2 −17.28 −2.63 −3.02 Adh6 −6.18 −1.54 −3.06 Ald3 −1.49 −1.83 2.13 Eno1 −1.75 −1.38 −2.26 Pdc6 −4.88 −2.16…
Fig. 2.1 The isoprenoid biosynthesis pathway-based opening/closing carbon flux strategies aiming at ART overproduction in A. annua L. ABA abscisic acid; DMAPP dimethylallyl diphosphate; DXP deoxyxylulose 5-phosphate; DXR DXP reductoisomerase; DXS…
