CHAPTER 31 Hemostasis Principles of investigation DH. Bevan, B. Sørensen Chapter contents INTRODUCTION 473 PHYSIOLOGY OF HEMOSTASIS APPLIED TO DIAGNOSIS 474 Primary hemostatis: formation of the platelet plug 474 Platelet…
CHAPTER 12 Macrocytic anemia R. Green Chapter contents MEGALOBLASTIC HEMOPOIESIS 197 Vitamin B12-related and folate-related causes of megaloblastic anemia 198 Vitamin B12 198 Folates 206 Vitamin B12-independent and folate-independent causes…
CHAPTER 34 Inherited disorders of coagulation NS. Key, JC. Boles Chapter contents INTRODUCTION 547 HEMOPHILIA 547 Inheritance 547 The molecular basis of hemophilia A and B (FVIII and FIX genes)…
CHAPTER 24 Chronic myelogenous leukemia G. Büsche, HH. Kreipe Chapter contents INTRODUCTION 361 CLINICAL FEATURES AND COURSE OF DISEASE 361 DIAGNOSTIC PROCEDURES 362 Genetics 362 Morphology 363 At diagnosis 363…
CHAPTER 9 Abnormalities of the structure and synthesis of hemoglobin SL. Thein Chapter contents INTRODUCTION 131 NORMAL HUMAN HEMOGLOBIN: STRUCTURE AND SYNTHESIS 131 INHERITED DISORDERS OF HEMOGLOBIN 133 THALASSEMIAS 134…
CHAPTER 10 Acquired hemolytic anemia DM. Arnold, I. Nazi, JC. Moore, NM. Heddle, JG. Kelton Chapter contents INTRODUCTION 157 CLINICAL AND LABORATORY FEATURES OF HEMOLYTIC ANEMIA 157 MECHANISMS OF HEMOLYSIS…
CHAPTER 16 Abnormalities in leukocyte morphology and number G. Zini Chapter contents NEUTROPHILS 247 Neutropenia 247 Congenital and idiopathic neutropenias 248 Acquired neutropenias 250 Infections associated with neutropenia 250 Drug-induced…
CHAPTER 14 Sideroblastic anemia A. May Chapter contents HEREDITARY SIDEROBLASTIC ANEMIA 225 X-linked inheritance 225 ALA synthase 2 defect 225 ABCB7 defect 228 Autosomal recessive sideroblastic anemia 228 Putative deficit…
CHAPTER 36 Natural anticoagulants and thrombophilia E. Norström, G. Escolar Chapter contents INTRODUCTION 583 COAGULATION 584 Classic cascade mechanism of coagulation vs. cell-based models of thrombin generation 584 Molecular mechanism…
CHAPTER 21 Molecular studies in myeloproliferative and myelodysplastic/myeloproliferative neoplasms O. Bock, HH. Kreipe Chapter contents INTRODUCTION 321 THE PHILADELPHIA CHROMOSOME AND BCR-ABL IN CHRONIC MYELOGENOUS LEUKEMIA 322 THE JANUS KINASE…
